An approach to natural insect repellent formulations: from basic research to technological development

Silva, Márcio Robert Mattos da; Ricci-Júnior, Eduardo

doi:10.1016/j.actatropica.2020.105419

Cited by 63 publications

(27 citation statements)

References 138 publications

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“…Pharmacological treatments for diseases transmitted by Aedes aegypti are palliative; the susceptibility to different types of viruses means that the use of such medicinal alternatives does not add much utility, and access to vaccines is not guaranteed to everyone who need them [ 6 ]. Barrier methods have been used to effectively decrease transmission of disease via mosquitoes, involving a set of strategies that incorporate methods to combat the vector and/or individual protection through the use of substances with repellent properties [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Identification of Potential New Aedes aegypti Juvenile Hormone Inhibitors from N-Acyl Piperidine Derivatives: A Bioinformatics Approach

Lima

Bastos

Ferreira

et al. 2022

IJMS

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Aedes aegypti mosquitoes transmit several human pathogens that cause millions of deaths worldwide, mainly in Latin America. The indiscriminate use of insecticides has resulted in the development of species resistance to some such compounds. Piperidine, a natural alkaloid isolated from Piper nigrum, has been used as a hit compound due to its larvicidal activity against Aedes aegypti. In the present study, piperidine derivatives were studied through in silico methods: pharmacophoric evaluation (PharmaGist), pharmacophoric virtual screening (Pharmit), ADME/Tox prediction (Preadmet/Derek 10.0®), docking calculations (AutoDock 4.2) and molecular dynamics (MD) simulation on GROMACS-5.1.4. MP-416 and MP-073 molecules exhibiting ΔG binding (MMPBSA −265.95 ± 1.32 kJ/mol and −124.412 ± 1.08 kJ/mol, respectively) and comparable to holo (ΔG binding = −216.21 ± 0.97) and pyriproxyfen (a well-known larvicidal, ΔG binding= −435.95 ± 2.06 kJ/mol). Considering future in vivo assays, we elaborated the theoretical synthetic route and made predictions of the synthetic accessibility (SA) (SwissADME), lipophilicity and water solubility (SwissADME) of the promising compounds identified in the present study. Our in silico results show that MP-416 and MP-073 molecules could be potent insecticides against the Aedes aegypti mosquitoes.

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Section: Introductionmentioning

confidence: 99%

Identification of Potential New Aedes aegypti Juvenile Hormone Inhibitors from N-Acyl Piperidine Derivatives: A Bioinformatics Approach

Lima

Bastos

Ferreira

et al. 2022

IJMS

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“…Trial and error assays showed that 10 ml of the blend of red wine and cider vinegar was the minimum optimal amount to attract flies to trap bottles. Thereby, three monoterpenoid compounds, namely 2-isopropyl-5-methylphenol (hereafter referred as thymol), 5-isopropyl-2-methylphenol (carvacrol), and 1,8-cineole (eucalyptol), were tested as potential disruptants of the bait attractiveness, given their proven repellency on different insect groups ( Evergetis et al 2018 , Oliveira et al 2018 , da Silva and Ricci-Júnior 2020 , Lee et al 2020 ). Carvacrol (98%) and eucalyptol (>97%) were obtained from Merck/Sigma–Aldrich (Madrid, Spain), while thymol (>98%) was acquired from Alfa Aesar (Karlsruhe, Germany).…”

Section: Methodsmentioning

confidence: 99%

Development of Novel Management Tools for Phortica variegata (Diptera: Drosophilidae), Vector of the Oriental Eyeworm, Thelazia callipaeda (Spirurida: Thelaziidae), in Europe

González

Bravo‐Barriga

Alarcón-Elbal

et al. 2021

Journal of Medical Entomology

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Lachryphagous males of Phortica variegata (Fallén, 1823) are gaining increasing attention in Europe, as they act as vectors of the nematode Thelazia callipaeda Railliet & Henry, 1910, causal agent of thelaziosis, an emergent zoonotic disease. Currently, there are no effective control strategies against the vector, and surveillance and monitoring rely on time-consuming and nonselective sampling methods. Our aim was to improve the knowledge about the population dynamics and the chemical ecology of the species. A total of 5,726 P. variegata flies (96.4% males and 3.6% females, mostly gravid) were collected in field experiments during June–September of 2020 in an oak forest in northern Spain. Our results indicate that 1) by means of sweep netting a significantly higher number of captures were found both around the collector´s body and in the air than at ground level; 2) a positive relationship was detected between the abundance of Phortica flies and temperature, with two significant peaks of abundance at 24 and 33°C; 3) the blend of red wine and cider vinegar was the most attractive bait; 4) yellow traps captured fewer flies compared to black and transparent traps; and 5) a significant reduction toward vinegar and wine was detected in presence of the phenolic monoterpenoid carvacrol. In addition, all the males (n = 690) analyzed by both molecular detection and dissection resulted negative for the presence of T. callipaeda larvae. Overall, these findings provide a better understanding of the vector in terms of monitoring and management strategies.

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“…The samples were prepared in triplicate and the same procedure was repeated for the standard solution. The TFC was expressed as Quercetin equivalents in per mL of LO [17].…”

Section: Total Flavonoid Content (Tfc) Estimationmentioning

confidence: 99%

Synthesis and Characterization of <i>Citrus limonum</i> Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

Kaur¹,

Pancham²,

Kaur³

et al. 2020

JBNB

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Lemon oil (LO), also known as Citrus limonum is a highly volatile essential oil (EO) with potential therapeutic properties like anti-oxidative, anti-proliferative, anti-fungal and anti-cancerous. However, the efficacy of LO is limited due to its physiological factors such as high volatility, poor stability (particularly sensitive to sunlight) and quick degradability upon exposure. To overcome these challenges, we formulated lemon oil loaded nanoemulsion system (LO-NE) (oil-in-water), using aqueous titration method. The formulation comprised of lemon oil (LO), Tween 80 and ethanol as oil, surfactant and co-surfactant phases respectively. The existence zone of NE was established by constructing pseudo-ternary phase diagrams using different concentrations of LO, surfactant and co-surfactant (S mix ). The quantitative estimation of LO was performed using a high throughput gas chromatography, revealing the presence of various compounds like Limonene, Alpha-Pinene and Linalyl acetate followed by the estimation of total phenolics and flavonoid content. The characterization of LO-NE indicated the particle size of 60 ± 2.5 nm along with the polydispersity index of 0.125 and zeta potential of −14.9 mV. The size range of the NE particles dispersed in the colloidal system was further verified by TEM micrograph which shows size range between 46.2 -104.7 nm. All the anti-oxidant assays outcomes exhibited the higher activity of LO-NE in comparison to LO alone with lower IC 50 values. The release kinetics statistical data showed that LO-NE had a sustained release and followed the Higuchi's model How to cite this paper:

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An approach to natural insect repellent formulations: from basic research to technological development

Cited by 63 publications

References 138 publications

Identification of Potential New Aedes aegypti Juvenile Hormone Inhibitors from N-Acyl Piperidine Derivatives: A Bioinformatics Approach

Identification of Potential New Aedes aegypti Juvenile Hormone Inhibitors from N-Acyl Piperidine Derivatives: A Bioinformatics Approach

Development of Novel Management Tools for Phortica variegata (Diptera: Drosophilidae), Vector of the Oriental Eyeworm, Thelazia callipaeda (Spirurida: Thelaziidae), in Europe

Synthesis and Characterization of <i>Citrus limonum</i> Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

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An approach to natural insect repellent formulations: from basic research to technological development

Cited by 63 publications

References 138 publications

Identification of Potential New Aedes aegypti Juvenile Hormone Inhibitors from N-Acyl Piperidine Derivatives: A Bioinformatics Approach

Identification of Potential New Aedes aegypti Juvenile Hormone Inhibitors from N-Acyl Piperidine Derivatives: A Bioinformatics Approach

Development of Novel Management Tools for Phortica variegata (Diptera: Drosophilidae), Vector of the Oriental Eyeworm, Thelazia callipaeda (Spirurida: Thelaziidae), in Europe

Synthesis and Characterization of &lt;i&gt;Citrus limonum&lt;/i&gt; Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application

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Synthesis and Characterization of <i>Citrus limonum</i> Essential Oil Based Nanoemulsion and Its Enhanced Antioxidant Activity with Stability for Transdermal Application