An Approach to “Middle Molecules” Identification in Artificial Kidney Dialysate, With Reference to Neuropathy Prevention

Man, N. K.; Terlain, Bernard; Paris, J; Werner, Georges; Sausse, A; Funck-Brentano, J. L.

doi:10.1097/00002480-197301900-00054

Cited by 62 publications

(16 citation statements)

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“…Funck-Brentano and co-workers followed up a fraction from uremic serum which inhibited in vitro nervous con duction in isolated frog nerve [14,21,22,42,44]. After having tried various chromatographic systems [21,44], it appears that the authors [22] changed to a technique derived from that of Fürst et al [24] for the rapid testing of small quantities of serum (separation on Sephadex G15, then DEAE Sephadex A25 on microcolumn but using experiment conditions different from those used by Fürst et al).…”

Section: Methods For the Study And Classification O F M Mmentioning

confidence: 99%

“…After having tried various chromatographic systems [21,44], it appears that the authors [22] changed to a technique derived from that of Fürst et al [24] for the rapid testing of small quantities of serum (separation on Sephadex G15, then DEAE Sephadex A25 on microcolumn but using experiment conditions different from those used by Fürst et al). They thus found on Sephadex G15 that only one peak (peak b) inhibited nervous conduction, that it had a MW estimated by filtration on cellulose membranes [22] to be between 600 and 1,300 daltons and that it could be sub divided on DEAE Sephadex A25 into 6 peaks, only one of which (peak b4.2) was positive in the test.…”

Section: Methods For the Study And Classification O F M Mmentioning

confidence: 99%

“…Biological fluids were collected from various types of CRF patients, according to the different studies: nondialyzcd patients [14,17,18,24,27,28,41,42,46,[49][50][51]57]; patients dialyzed by different techniques: peritoneal dialy sis [24,28], hemodialysis [1-3,12,14,17,21,24,28,29,31,41, 44.45.50.53.55.57] ; dialyzed patients developing pericar ditis [24,55] or polyneuritis [14,21,24,44]; or CRF pa tients with high levels of creatinine urea [1][2][3]7],…”

Section: Patientsmentioning

confidence: 99%

“…Among the various studies, the fluids analyzed were (table I): serum or plasma of normal or uremic subjects [12, 14, 17, 18, 22, 24, 27-29, 31, 36, 39, 41, 45, 46, 49, 50, 53.55.57] ; urine [12,14,18,21,24,28,40,42,46,[49][50][51]57]; dialyzates obtained from dialysis on different types of membrane [1, 10,12,14,28,31,[44][45][46]53,54] and under var ious conditions: opened [53,54] or closed [53] dialysis, hemoperfusion [41], ultrafiltration [53,60], collection of dialyzate during the first 30 min of dialysis [34] or after 2 and 24 h [24]; cerebrospinal fluid [41]; pericardial fluid [41].…”

Section: Biological Fluidsmentioning

confidence: 99%

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Molecules in the Middle Molecular Weight Range

Contreras¹,

Later²,

Navarro³

et al. 1982

Nephron

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Section: Methods For the Study And Classification O F M Mmentioning

confidence: 99%

Section: Methods For the Study And Classification O F M Mmentioning

confidence: 99%

Section: Patientsmentioning

confidence: 99%

Section: Biological Fluidsmentioning

confidence: 99%

See 2 more Smart Citations

Molecules in the Middle Molecular Weight Range

Contreras¹,

Later²,

Navarro³

et al. 1982

Nephron

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“…However, they drew con troversial conclusions: along with studies in which an improvement o f the nerve conduc tion velocity (NCV) is evident [16,17], there are others [18] in which no significant varia tion was found either by clinical or by neuro physiological tests [19].…”

Section: Introductionmentioning

confidence: 99%

Uremic Neuropathy: Clinical and Neurophysiological Investigation of Dialysis Patients Using Different Chemical Membranes

Violante

Lorenzi²,

Fusello³

1985

Eur Neurol

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A clinical and neurophysiological study was carried out in a group of dialyzed patients suffering from uremic neuropathy in order to determine whether the use of different dialysis membranes can influence their clinical and neurophysiological parameters. The patients were divided into two groups: one group was dialyzed with Cuprophan (CUP) the other with polyacrylonitrile (PAN) membranes. Comparison of the two groups showed that the PAN membrane was more effective than the CUP membrane, both at the clinical and at the neurophysiological (nerve conduction velocity) levels. The patients who used the PAN membrane were also found to have lower blood PTH and magnesium levels. This difference was statistically significant. These preliminary results seem to confirm the hypothesis of the neurotoxicity of middle molecules in uremic neuropathy.

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Membranen in der medizinischen Verfahrenstechnik

Chmiel

Strathmann

Streicher

et al. 1983

Chemie Ingenieur Technik

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Membranes in medical process engineering. Synthctic membranes not only represent the essential components of an artificial kidney or an artificial lung but are also used as wound dressing and in systems for controlled release ofdrugs in certain long-term therapeutic measures or as part of an artificial pancreas. By far the greatest present economic significance ofmembranes is their use in the so-called artificial kidney. Considerable cost saving would result if patients could undertake "home dialysis". This requires the development of new, simpler artificial kidneys and thus highzrperformance membranes. The latest trend in "artificial kidneys", the so-called method of "hemodiafiltration" warants special mention. The separation process is no longer effected only by diffusion but also by convection, i. e. the driving force is the pressuredifference between the two sides of the membrane. This paper addresses problems encountered in the development and use of membranes in medicine, recent applications such as the controlled release of active components, or plasma separation. and demonstrates the potential of membranes in medicine.

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An Approach to “Middle Molecules” Identification in Artificial Kidney Dialysate, With Reference to Neuropathy Prevention

Cited by 62 publications

References 0 publications

Molecules in the Middle Molecular Weight Range

Molecules in the Middle Molecular Weight Range

Uremic Neuropathy: Clinical and Neurophysiological Investigation of Dialysis Patients Using Different Chemical Membranes

Membranen in der medizinischen Verfahrenstechnik

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