An approach to develop two-dimensional fingerprint for the quality control of Qingkailing injection by high-performance liquid chromatography with diode array detection

Yan, Shaomin; Xin, Wenfeng; Luo, Guoan; Wang, Yiming; Cheng, Yiyu

doi:10.1016/j.chroma.2005.07.066

Cited by 119 publications

(75 citation statements)

References 22 publications

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“…(13) and (15), when [Br − ] in the system is lower than [Br − ] crit , the contention of 3 BrO − to 2 HBrO has predominated so that course D takes place. Course D is as follows:…”

Section: Basic Principle Of Electrochemical Fingerprintmentioning

confidence: 97%

“…The mechanism of the B-Z oscillatory reaction to employ 3 BrO − , 3 Ce + and malonic acid as original reactants involves almost thirty elementary reactions [22] . However, these reactions may be merged into two complex reactions, namely inductive and oscillatory reactions [22,23] .…”

Section: Basic Principle Of Electrochemical Fingerprintmentioning

confidence: 99%

“…The fingerprint technique of CTM also emerged as the needs of the times, and its important actions in the differentiation, evaluation and quality control of CTMs have been realized widely by people [2] . At present, among the various fingerprint techniques reported in literitures [3][4][5][6][7][8][9][10][11][12][13][14][15] , the research and application of the chromatographic fingerprints of CTMs are the most prevalent and in-depth, and the fingerprint technique has presently become the best and internationally accepted measure to evaluate and control the qualities of CTMs and other natural medicines. However, the chromatographic fingerprint technique has also un-neglectable limitations, the research on the method by which the fingerprints to show the throng character of all chemical components in each state of CTM may directly be determined without pretreatments such as separation and purification has become one of primary tasks which the analysts are facing.…”

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confidence: 99%

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Principle, traits and functions of electrochemical fingerprint of Chinese traditional medicine

et al. 2007

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In regard to such challenging analysis problems as scientific identification and quality evaluation of Chinese traditional medicine, the electrochemical fingerprint technique of Chinese traditional medicine has been researched. The principle, traits, functions, etc., of the electrochemical fingerprint have detailedly been analyzed and discussed by the B-Z oscillatory system using malonic acid as main dissipation substance, characterized by the fact that different influences of different Chinese traditional medicines on the mechanism of the oscillatory reaction cause different changes of the shape of the potential-time curve of the oscillatory system under the conditions of constant temperature and pressure. An economical, simple and convenient, easy pushing and effective scientific method for distinguishing and evaluating multifarious Chinese traditional medicines has successfully been put forward. electrochemical fingerprint, principle, trait, function, differentiation of verity and falsity, quality evaluation, Chinese traditional medicine Comparing with the western medicine, because of its low side-effects, the applications of Chinese traditional medicine (CTM) have been paid much attention to by people. However, as it was mentioned in ref.[1], the sorts of CTMs are very various; the medicinal sources are complex; in different areas, the customs to use the medicines are different; the homonym and synonym phenomena are very prevalent; because of the lack of effective criterions for controlling and evaluating the qualities of CTMs, the phenomena of mixing the false with the genuine and selling the shoddy medicines often take place. Those have badly restricted the security of employing CTMs and the stabilization of the curative effects, and have also restricted the developments of the research and application of CTMs. Therefore, none but scientific identification and quality evaluation to CTM can ensure the employ security and stabilization of the curative effect of the CTM, providing the entrance of CTM into the international medicine market with the quality guarantee. The fingerprint technique of CTM also emerged as the needs of the times, and its important actions in the differentiation, evaluation and quality control of CTMs have been realized widely by people [2] . At present, among the various fingerprint techniques reported in literitures [3][4][5][6][7][8][9][10][11][12][13][14][15] , the research and application of the chromatographic fingerprints of CTMs are the most prevalent and in-depth, and the fingerprint technique has presently become the best and internationally accepted measure to evaluate and control the qualities of CTMs and other natural medicines. However, the chromatographic fingerprint technique has also un-neglectable limitations, the research on the method by which the fingerprints to show the throng character of all chemical components in each state of CTM may directly be determined without pretreatments such as separation and purification has become one of primary tasks which

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“…(13) and (15), when [Br − ] in the system is lower than [Br − ] crit , the contention of 3 BrO − to 2 HBrO has predominated so that course D takes place. Course D is as follows:…”

Section: Basic Principle Of Electrochemical Fingerprintmentioning

confidence: 97%

Section: Basic Principle Of Electrochemical Fingerprintmentioning

confidence: 99%

mentioning

confidence: 99%

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Principle, traits and functions of electrochemical fingerprint of Chinese traditional medicine

et al. 2007

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“…Compared with conventional fingerprint, enhanced fingerprint with additional spectral information contained, has many more advantages. Firstly, it contains more peaks which can not be detected at a fixed wavelength but have UV responses at other wavelengths; Secondly, in quality assessment, conventional fingerprint might give different chromatographic patterns at different wavelengths, whereas enhanced fingerprint technique is more objective and credible [11]. By using the fingerprint analysis, a particular herb can be identified and distinguished from some closely related species.…”

Section: Introductionmentioning

confidence: 98%

Fingerprint profile of active components for Andrographis paniculata Nees by HPLC-DAD

Cui

Wang

Ouyang

et al. 2009

Sens. & Instrumen. Food Qual.

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Andrographis paniculata Nees (A. paniculata) has been used as herbal medicine for thousands of years in China. In this work, a quick extraction method with microwave-assisted treatment was studied for a complete extraction of active compounds from A. paniculata. Furthermore, the proposed fingerprint method, enhanced fingerprint by HPLC-DAD, has the advantage of efficiency and accuracy. In comparison with common fingerprint at fixed wavelength, enhanced fingerprint compiled additional spectral data and was hence more informative. It could efficiently identify, distinguish and assess A. paniculata. So it could be used to conduct the quality control of this traditional Chinese medicine comprehensively.

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“…PCA was then performed on the two-dimensional fingerprints and samples grouped according to chromatographic and spectrophotometric profile. It was suggested that the two-dimensional fingerprint was more discriminatory than simply using the chromatogram at a single wavelength (Yan et al, 2005).…”

Section: Data Processing and Chemometricsmentioning

confidence: 99%

Comprehensive multi‐dimensional liquid chromatographic separation in biomedical and pharmaceutical analysis: a review

Dixon

Pitfield

Perrett

2006

Biomedical Chromatography

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‘Multi‐dimensional’ liquid separations have a history almost as long as chromatography. In multi‐dimensional chromatography the sample is subjected to more than one separation mechanism; each mechanism is considered an independent separation dimension. The separations can be carried out either offline via fraction collection, or directly coupled online. Early multi‐dimensional separations using combinations of paper chromatography, electrophoresis and gels, in both planar and columnar modes are reviewed. Developments in HPLC have increased the number of measurable analytes in ever more complex matrices, and this has led to the concept of ‘global metabolite profiling’. This review focuses on the theory and practice of modern ‘comprehensive’ multi‐dimensional liquid chromatography when applied to biomedical and pharmaceutical analysis. Copyright © 2006 John Wiley & Sons, Ltd.

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An approach to develop two-dimensional fingerprint for the quality control of Qingkailing injection by high-performance liquid chromatography with diode array detection

Cited by 119 publications

References 22 publications

Principle, traits and functions of electrochemical fingerprint of Chinese traditional medicine

Principle, traits and functions of electrochemical fingerprint of Chinese traditional medicine

Fingerprint profile of active components for Andrographis paniculata Nees by HPLC-DAD

Comprehensive multi‐dimensional liquid chromatographic separation in biomedical and pharmaceutical analysis: a review

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