An approach to determine critical process parameters for ethanol precipitation process of Danhong injection

Yan, Binjun; Guo, Zheng-Tai; Qu, Haibin; Zhao, Buchang; Zhao, Tao

doi:10.4268/cjcmm20131105

Cited by 5 publications

(1 citation statement)

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“…Finally, the extract is dissolved in glucose solution and the pH value adjusted. All production process occur under strict aseptic conditions, and the quality control measures used for the process have been reported (Binjun et al, 2013;Yan et al, 2015;Zheng et al, 2015). DHI is formulated according to the theory of TCM and has been used, alone or in combination with other therapies, for treatment of a variety of diseases in China for many years (Sun et al, 2009;He et al, 2012;Zhang et al, 2016;Feng et al, 2019;You et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Danhong Injection for the Treatment of Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

Yan

Qian

et al. 2020

Front. Pharmacol.

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Objective: Danhong Injection (DHI) has been widely used to treat various diseases in China for many years. The objective of this systematic review was to evaluate the efficacy of DHI combined with antihypertensive drugs for treatment of hypertensive nephropathy.Methods: Seven databases were searched from inception to September 21st, 2019. Randomized controlled trials comparing DHI combined with antihypertensive drugs versus antihypertensive drugs alone were extracted. The primary outcome was microalbuminuria (mALB). Secondary outcomes included systolic blood pressure (SBP), diastolic blood pressure (DBP), and serum creatinine (SCr).Results: Fifteen studies were included in the meta-analysis, which indicated that DHI combined with antihypertensive drugs has advantages compared with antihypertensive drugs alone for reducing mALB [weighted mean difference (WMD) = −12.86, 95% confidence interval (CI) (−14.72, −11.0),

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Section: Introductionmentioning

confidence: 99%

Danhong Injection for the Treatment of Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

Yan

Qian

et al. 2020

Front. Pharmacol.

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Critical process parameter identification of manufacturing processes of Astragali Radix extract with a weighted determination coefficient method

Sun

Yang

Cao

et al. 2020

Chinese Herbal Medicines

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Research progress on the ethanol precipitation process of traditional Chinese medicine

et al. 2020

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Ethanol precipitation is a purification process widely used in the purification of Chinese medicine concentrates. This article reviews the research progress on the process mechanism of ethanol precipitation, ethanol precipitation process application for bioactive component purification, ethanol precipitation and traditional Chinese medicine quality, ethanol precipitation equipment, critical parameters, parameter research methods, process modeling and calculation methods, and process monitoring technology. This review proposes that ethanol precipitation technology should be further developed in terms of five aspects, namely, an in-depth study of the mechanism, further study of the effects on traditional Chinese medicine quality, improvement of the quality control of concentrates, development of new process detection methods, and development of a complete intelligent set of equipment.

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An approach to determine critical process parameters for ethanol precipitation process of Danhong injection

Cited by 5 publications

References 0 publications

Danhong Injection for the Treatment of Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

Danhong Injection for the Treatment of Hypertensive Nephropathy: A Systematic Review and Meta-Analysis

Critical process parameter identification of manufacturing processes of Astragali Radix extract with a weighted determination coefficient method

Research progress on the ethanol precipitation process of traditional Chinese medicine

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