volume 2, issue 3, P1-12 2017
DOI: 10.15226/2475-4714/2/3/00126
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Abstract: The extensive use of antibiotics in hospitals and community since their introduction into medical practice has created major evolutionary pressures in bacteria to develop various resistance mechanisms. This phenomenon has led to increased morbidity, mortality and health care costs. The search for new antibacterial agents directed towards novel targets became highly imperative. The biosynthetic pathway of cytoplasmic peptidoglycan precursor is currently gaining much interest as a target site for antibacterial t…

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