An Approach for Drug Delivery to the Brain Via External Acoustic Meatus

Abstract

Depression is momentous mood chaos marked by a mixture of symptoms that interfere with a person’s daily activities. The oral administration serves dose dumping issues of therapeutic molecules in specially targeted delivery. So, the external auditory canal pathway was explored to deliver the API and it help to bypass the above-mentioned problem. Sonication bath method was used to prepare bio-nanosuspension loaded with escitalopram and biopolymer extracted from Tagetes patula. Different ratios of drug and biopolymer were considered and 10 formulations were formulated followed by evaluation parameters like SEM, FTIR for biopolymer and ex-vivo, stability, drug release studies, etc., for the final formulation was performed. Formulations were examined through many evaluation parameters, such as content uniformity, pH, in-vitro drug release, and many more. It was found that STP 1 (1:0.5) was the best formulation. From pharmacokinetic data and in-vitro studies revealed and concluded that acoustic meatus is a feasible pathway for molecules delivery to the brain for depression treatment.