Einstein’s theory of general relativity is playing an increasingly important role in fields such as interplanetary navigation, astrometry, and metrology. Modern spacecraft and interplanetary probe prediction and estimation platforms employ a perturbed Newtonian framework, supplemented with the Einstein-Infeld-Hoffmann n-body equations of motion. While time in Newtonian mechanics is formally universal, the accuracy of modern radiometric tracking systems necessitate linear corrections via increasingly complex and error-prone post-Newtonian techniques—to account for light deflection due to the solar system bodies. With flagship projects such as the ESA/JAXA BepiColombo mission now operating at unprecedented levels of accuracy, we believe the standard corrected Newtonian paradigm is approaching its limits in terms of complexity. In this paper, we employ a novel prototype software, General Relativistic Accelerometer-based Propagation Environment, to reconstruct the Cassini cruise-phase trajectory during its first gravitational wave experiment in a fully relativistic framework. The results presented herein agree with post-processed trajectory information obtained from NASA’s SPICE kernels at the order of centimetres.