An Application of Plastic Microchannel-Microheater Chips to a Thermal Synthetic Reaction

Kitamura, Noboru; Hosoda, Yukiko; Ueno, Kosei; Iwata, Satoshi

doi:10.2116/analsci.20.783

Cited by 12 publications

(12 citation statements)

References 20 publications

(11 reference statements)

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“…1c. [13][14][15][16][17][18] Typically, a thin metal film (Pt, Au, or Ag) is deposited directly onto a PSt substrate in vacuum and the structure of a microelectrode/microheater on the PSt substrate is fabricated by photolithography/etching of the metal layer. The microelectrode/ microheater is then buried into the PSt substrate by pressing the substrate between two glass plates at 108˚C.…”

Section: Fabrication Of Polymer Microchips and Microchemical Techniqumentioning

confidence: 99%

“…3. [13][14][15][16][17][18] For spectroscopic measurements, incident light from an Xe lamp or laser is introduced to an optical microscope through an objective lens and irradiated to the sample solution in the microchannel chip placed on the stage of the microscope: irradiated spot size = 2 -3 mm. For absorption spectroscopy, transmitted light passed through the sample solution is reflected by a half mirror set below the microscope stage and introduced to a photodetector to record an absorption spectrum.…”

Section: ·2 Microspectroscopy and Microelectrochemistry Systemsmentioning

confidence: 99%

“…By setting appropriate flow rate and applied voltage, one can control arbitrarily the temperature profile in a microchannel. 15,18 Realizing such performances of the microchannel-microheater chip, we conducted the thermal synthetic reaction between malononitrile (MN) and benzaldehyde (BA) in methanol by using microchannel-microheater chips. 18 Methanol solutions of MN and BA were introduced separately to the Y-structured microchannel-microheater chip at the same flow rate and the two solutions were allowed to mix in the downstream side of the channel junction.…”

Section: ·4·3 Thermal Reaction In Microchannel-microheater Chipsmentioning

confidence: 99%

“…Under the optimum conditions (u = 0.1 mL/min and heater width = 200 mm), the BMN yield was as high as 96% with the reaction time of 84 s, while that obtained by refluxing a bulk reaction mixture for 4 h was ~70%. 18 It is supposed that the reaction yield should be the same thermodynamically and kinetically for both chip and bulk systems. Nevertheless, the reaction yield was observed to be higher in the microchip as compared with that in a bulk system.…”

Section: ·4·3 Thermal Reaction In Microchannel-microheater Chipsmentioning

confidence: 99%

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Polymer Channel Chips as Versatile Tools in Microchemistry

2008

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The paper describes the fabrication and chemical applications of polymer microchannel chips, with special reference to in situ observations of the chemical/physical processes occurring in polystyrene microchannel chips, including those in microchannel-microelectrode/microheater chips. On the basis of absorption/fluorescence microspectroscopy and microelectrochemistry techniques, we show some characteristic features of liquid/liquid extraction, electrochemical responses, and photochemical/electrochemical/thermal synthetic reactions in microchannel chips.

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Section: Fabrication Of Polymer Microchips and Microchemical Techniqumentioning

confidence: 99%

Section: ·2 Microspectroscopy and Microelectrochemistry Systemsmentioning

confidence: 99%

Section: ·4·3 Thermal Reaction In Microchannel-microheater Chipsmentioning

confidence: 99%

Section: ·4·3 Thermal Reaction In Microchannel-microheater Chipsmentioning

confidence: 99%

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Polymer Channel Chips as Versatile Tools in Microchemistry

2008

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“…It is now widely recognized that chemical reaction, separation, and/or detection systems can be integrated on a single microchip and that various chemical operations can be conducted along solution-flow in a microchannel. [12][13][14][15][16][17][18][19][20][21][22][23] A microchannel-microheater chip has been also reported. In a minute space such as in a microchannel integrated with a heater, local cooling/heating proceeds very quickly owing to large surface area/volume ratios of both microheater and michrochannel.…”

Section: Introductionmentioning

confidence: 99%

Raman Microspectroscopy/Imaging Study on Phase-Vanishing Processes of Fluorous Biphase Systems in Microchannel-Microheater Chips

et al. 2006

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Temperature-dependent phase-vanishing processes between perfluorohexane (FC-72) and n-heptane (C7H16, volume ratio of 1:1 and phase-vanishing temperature > 41˚C), were studied in a glass microchannel-microheater chip under solutionflow conditions. Without applying a voltage to the heater at 21˚C, the two liquids in the microchannel were separated into two streams at a solution flow rate (v) of 0.975 cm/s, while the phase boundary between FC-72 and C7H16 vanished in the downstream side of the heater at V = 4.5 V. Then, we conducted Raman intensity imaging during the phase vanishing processes in the microchannel by monitoring the band at 756 (FC-72) or 1456 cm -1 (C7H16). At V = 4.5 V and v = 0.975 cm/s, although no phase boundary between the two liquids in the microchannel was observed, the relevant Raman intensity images indicated the inhomogeneous nature of the solution, and distribution of C7H16 to the FC-72 phase along with solution flow was observed.

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Monolithic fabrication of electro-fluidic polymer microchips

et al. 2008

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Integration of electronic wiring with microfluidic chips is an important process as it allows electrical interactions with the fluidic media, for example required for resistive and capacitive sensing. It is also necessary in order to implement various actuation and control mechanisms such as pumping, electrophoresis and temperature control. Typically electrical wire traces are added to microfabricated fluidic chips using metal deposition processes that are carried out after the fluidic chip has been fabricated. The process for adding the wiring is complicated and is limited to select metals that can be deposited by evaporation or sputtering. We present a single step method for integrating electrical wires into polymer microfluidic chips that are fabricated by a hot embossing process. This process can flexibly embed any kind of commercially available metal wire with a microfluidic chip and the wiring may be integrated to come into surface contact with the fluid or may be embedded in close proximity to (but insulated from)the fluid paths for example for local heating purposes. This method significantly reduces total processing time and is thus a valuable method for wire integration into polymer chips. We demonstrate two applications-a microelectrolysis chip and a heater chip that were fabricated using this methodology. The design, fabrication process and the initial test results are presented.

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An Application of Plastic Microchannel-Microheater Chips to a Thermal Synthetic Reaction

Cited by 12 publications

References 20 publications

Polymer Channel Chips as Versatile Tools in Microchemistry

Polymer Channel Chips as Versatile Tools in Microchemistry

Raman Microspectroscopy/Imaging Study on Phase-Vanishing Processes of Fluorous Biphase Systems in Microchannel-Microheater Chips

Monolithic fabrication of electro-fluidic polymer microchips

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