We prove Cameron-Martin type quasi-invariance results for the heat kernel measure of infinite-dimensional Kolmogorov and related diffusions. We first study quantitative functional inequalities for appropriate finite-dimensional approximations of these diffusions, and we prove these inequalities hold with dimension-independent coefficients. Applying an approach developed in [5, 10,11], these uniform bounds may then be used to prove that the heat kernel measure for certain of these infinite-dimensional diffusions is quasi-invariant under changes of the initial state. Contents 1. Introduction 1 2. Wang's Harnack inequality for finite-dimensional diffusions 4 2.1. Kolmogorov diffusions 4 2.2. Generalized Kolmogorov diffusions 6 3. Infinite-dimensional results 13 3.1. Infinite-dimensional Kolmogorov diffusion 15 3.2. Generalized Kolmogorov diffusions 18 References 26 Primary 60J60, 28C20; Secondary 35H10