An Apparatus for the Graphic Recording of Oxygen Consumption and Carbon Dioxide output, especially adapted for Clinical Work

Hagedorn, Hans Christian

doi:10.1042/bj0181301

Cited by 15 publications

(4 citation statements)

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“…Oxygen consumption (VO2), carbon dioxide generation (VCO2), and respiratory quotient (RQ), which is the ratio of VCO2 to VO2, are essential measures of metabolism 1 , 2 . For more than 100 years, investigators have been exploring methods of measuring VO2 and VCO2 3 and much research in recent years has focused on their clinical applications 4 , 5 . Indirect calorimetry is a non-invasive method, in which VO2 and VCO2 are measured from inhalation and exhalation of a subject 6 – 8 .…”

Section: Introductionmentioning

confidence: 99%

A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption

Shinozaki

Okuma

Saeki

et al. 2021

Sci Rep

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Using a new method for measuring the molecular ratio (R) of inhalation to exhalation, we investigated the effect of high fraction of inspired oxygen (FIO2) on oxygen consumption (VO2), carbon dioxide generation (VCO2), and respiratory quotient (RQ) in mechanically ventilated rats. Twelve rats were equally assigned into two groups by anesthetics: intravenous midazolam/fentanyl vs. inhaled isoflurane. R, VO2, VCO2, and RQ were measured at FIO2 0.3 or 1.0. R error was ± 0.003. R was 1.0099 ± 0.0023 with isoflurane and 1.0074 ± 0.0018 with midazolam/fentanyl. R was 1.0081 ± 0.0017 at an FIO2 of 0.3 and 1.0092 ± 0.0029 at an FIO2 of 1.0. There were no differences in VCO2 among the groups. VO2 increased at FIO2 1.0, which was more notable when midazolam/fentanyl was used (isoflurane-FIO2 0.3: 15.4 ± 1.1; isoflurane-FIO2 1.0: 17.2 ± 1.8; midazolam/fentanyl-FIO2 0.3: 15.4 ± 1.1; midazolam/fentanyl-FIO2 1.0: 21.0 ± 2.2 mL/kg/min at STP). The RQ was lower at FIO2 1.0 than FIO2 0.3 (isoflurane-FIO2 0.3: 0.80 ± 0.07; isoflurane-FIO2 1.0: 0.71 ± 0.05; midazolam/fentanyl-FIO2 0.3: 0.79 ± 0.03; midazolam/fentanyl-FIO2 1.0: 0.59 ± 0.04). R was not affected by either anesthetics or FIO2. Inspired 100% O2 increased VO2 and decreased RQ, which might be more remarkable when midazolam/fentanyl was used.

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Section: Introductionmentioning

confidence: 99%

A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption

Shinozaki

Okuma

Saeki

et al. 2021

Sci Rep

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“…Auch andere V erfahren wie die Messung der V olum endifferenzen der E xspirationsluft m it G asuhren vor und nach C 0 2-A bsorption [5] bzw. m ittels zweier KROGHscher Spirom eter [9], die eine fortlaufende C 0 2-Messung erm öglichten, w aren fü r eine gleichzeitig durchzuführende L ungenfunktionsanalyse nicht geeig n et. Schließlich gelang F l e is c h [6] m it der K onstruktion seines M eta llographen eine sim ultane C 0 2-bzw.…”

Section: üBer Eine Fortlaufende Bestimmung Der Kohlendioxydausscheiduunclassified

Über eine fortlaufende Bestimmung der Kohlendioxydausscheidung und des respiratorischen Quotienten während Lungenfunktionsanalysen

Mürtz¹,

Begenat²

1967

Respiration

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“…Since it is non-invasive, indirect calorimetry has been widely used by clinicians (11,12) as well as animal studies (13)(14)(15)(16) . However, due to the lack of a gold standard, the accuracy has been questioned for nearly 100 years (6,7,17,18) . One of the traditional but standard methods is the Douglas Bag (DB) collection technique, which was rst introduced by a physiologist, Claude Gordon Douglas, in 1911 (19) .…”

Section: Introductionmentioning

confidence: 99%

Continuous and repeat metabolic measurements compared between post-cardiothoracic surgery and critical care patients

Shinozaki

Zhou

et al. 2023

Preprint

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Objective: Using a system, which accuracy is equivalent to the gold standard Douglas Bag (DB) technique for measuring oxygen consumption (VO2), carbon dioxide generation (VCO2), and respiratory quotient (RQ), we aimed to continuously measure these metabolic indicators and compare the values between post-cardiothoracic surgery and critical care patients. Methods: This was a prospective, observational study conducted at a suburban, quaternary care teaching hospital. Age 18 years or older healthy volunteers and patients who underwent mechanical ventilation were enrolled. Results: We included 4 post-surgery and 6 critical care patients. Of those, 3 critical care patients died. The longest measurement reached to 12 hrs and 15 minutes and 50 cycles of repeat measurements were performed. VO2 of the post-surgery patients were 234 +/- 14, 262 +/- 27, 212 +/- 16, and 192 +/- 20 mL/min, and those of critical care patients were 122 +/- 20, 189 +/- 9, 191 +/- 7, 191 +/- 24, 212 +/- 12, and 135 +/- 21 mL/min, respectively. The value of VO2 was more variable in the post-surgery patients and the range of each patient was 44, 126, 71, and 67, respectively. Generalized linear mixed-effect model identified that the post-surgery patients had higher VO2 than the critical care patients (p<0.01). The post-surgery patients also had higher VCO2 than critical care patients (p<0.01). There were no significant differences in RQ between the two groups. Conclusions: We developed an accurate system that enables continuous and repeat measurements of VO2, VCO2, and RQ. Critical care patients may have less activity in metabolism represented by lower values of VO2 and VCO2, which were less variable over time as compared to those of post-cardiothoracic surgery patients.

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An Apparatus for the Graphic Recording of Oxygen Consumption and Carbon Dioxide output, especially adapted for Clinical Work

Cited by 15 publications

References 0 publications

A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption

A method for measuring the molecular ratio of inhalation to exhalation and effect of inspired oxygen levels on oxygen consumption

Über eine fortlaufende Bestimmung der Kohlendioxydausscheidung und des respiratorischen Quotienten während Lungenfunktionsanalysen

Continuous and repeat metabolic measurements compared between post-cardiothoracic surgery and critical care patients

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