“…In continuation of this work, we isolated a new N-methylaristolactam from Piper caldense. This is the second report of a naturally occurring Nmethylaristolactam althought such compounds have been synthesized (Castedo et al, 1976), and N-methyl derivatives of 4,5-dioxoaporphines, the proposed biosynthetic precursors of aristolactams, have been reported (Desai et al, 1988;Mahmood et al, 1986;Hänsel et al, 1976;Singh et al, 1996;Achenbach et al, 1991). …”