An apiose-containing coumarin glycoside from gmelina arborea root

Satyanarayana, P.; Subrahmanyam, P.; Kasai, Ryoji; Tanaka, Osamu

doi:10.1016/s0031-9422(00)82575-3

Cited by 30 publications

(22 citation statements)

References 6 publications

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“…Lignans such as arboreol, isoarboreol, methyl arboreol, arborone, gmelanone, gummadiol, and 7-oxodihydrogmelinol [4][5][6] have been isolated from heartwood of the plant. Few coumarin glycosides [7] and iridoid glycosides [8] have been reported in roots and leaves, respectively. Three iridoid glycosides 6-O-(3-O-benzoyl)--l-rhamnopyranosylcatalpol, 6-O-(3-O-transcinnamoyl)--l-rhamnopyranosylcatalpol a n d 6 -O -( 3  -O -c i s -c i n n a m o y l ) - -lrhamnopyranosylcatalpol were isolated from aerial parts of G. arborea and structures were elucidated by spectral analysis.…”

Section: Introductionmentioning

confidence: 99%

Toxicity study and analgesic activity of Gmelina arborea extract and its fractions

Kulkarni¹,

Shah²,

Chavan³

2013

J Nat Pharm

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Gmelina arborea is an important medicinal plant in the traditional system of medicine in India. The present study was designed to evaluate toxicity and analgesic activity of the alcoholic extract (AlcE) of G. arborea stem bark and its various fractions. The AlcE was prepared by the Soxhlet extraction technique. AlcE was fractionated with petroleum ether, chloroform, ethyl acetate, and n-butanol. The acute toxicity of AlcE and its fractions was studied in female Swiss albino mice using the OECD guidelines. In the acute toxicity test, mice were treated with AlcE and its fractions (2000 mg/kg), orally. Animals were observed periodically during the fi rst 24 h after administration and daily thereafter for 14 days. The analgesic activity was studied in Swiss albino mice by using acetic acid-induced writhing method. The AlcE (250 and 500 mg/kg) and its fractions (200 mg/kg) were administered to animals before 45 minutes of administration of acetic acid. The number of muscular contractions was counted over a period of 10 minutes after acetic acid injection. AlcE and its fractions did not produce mortality, changes in behavior or any other physiological activities in mice, at selected dose. The AlcE at 250 and 500 mg/kg showed a signifi cant decrease in writhes -13.4 ± 0.16 and 12.2 ± 0.22, respectively when compared with control (19.2 ± 0.58). The n-butanol fraction showed maximum inhibition of writhes (57.37%) as compared to other fractions. These fi ndings suggested that AlcE and its fractions are safe after oral administration and have signifi cant analgesic activity.

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Section: Introductionmentioning

confidence: 99%

Toxicity study and analgesic activity of Gmelina arborea extract and its fractions

Kulkarni¹,

Shah²,

Chavan³

2013

J Nat Pharm

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“…1S-40S). [6] and two sugar moieties in 1. The 13 C NMR spectrum also exhibited the signals due to coumarin aglycone and two glucopyranosyl moieties [7].…”

Section: Supporting Informationmentioning

confidence: 99%

“…Effects of compounds 1,3,5,6,8,9, and 13 on the survival rate of PC12 cells injured by serum deprivation (10 µM). # P < 0.001 vs. control, * p < 0.05 vs. model, ** p < 0.01 vs. model, *** p < 0.001 vs. model, a positive control substance…”

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confidence: 99%

Coumarin Glycosides and Iridoid Glucosides with Neuroprotective Effects from Hydrangea paniculata

Shi

Yang

et al. 2012

Planta Med

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Five new coumarin glycosides, umbelliferone 7-O-sophoroside (1), umbelliferone 7-O-β-D-glucopyranosyl(1 → 3)-β-D-glucopyranoside (2), umbelliferone 7-O-β-D-glucopyranosyl(1 → 3)-[β-D-apiofuranosyl(1 → 6)]-β-D-glucopyranoside (3), umbelliferone 7-O-β-D-glucopyranosyl(1 → 2)-β-D-apiofuranosyl(1 → 6)-β-D-glucopyranoside (4), and umbelliferone 7-O-β-D-glucopyranosyl(1 → 5)-β-D-apiofuranosyl(1 → 6)-β-D-glucopyranoside (5), and two new iridoid glucosides, 7-O-E-isoferuloyl loganic acid (6) and 7-O-β-D-glucopyranosyl loganin (7), together with eight known compounds (8-15) were isolated from the stems of Hydrangea paniculata. Their structures were established by spectroscopic analysis and chemical methods. At 10 µM, compounds 1, 3, 5, 6, 8, 9, and 13 showed neuroprotective effects against serum deprivation-induced PC12 cell damage.

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“…Compounds 2 and 3 are also simple coumarin glycosides. 2 and 3 were identified as apiosylskimmin 28) and hymexelsin 29) by comparison of their structural data with those of authentic samples.…”

Section: Studies Of Coumarins From the Chinese Drug Qianhu XXVII 1) mentioning

confidence: 99%

Studies of Coumarins from the Chinese Drug Qianhu, XXVII: Structure of a New Simple Coumarin Glycoside from Bai-Hua Qianhu, Peucedanum praeruptorum

Ishii

Okada

Baba

et al. 2008

CHEMICAL & PHARMACEUTICAL BULLETIN

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A new simple coumarin glycoside, named praeroside VI (1), along with six known coumarins, were isolated from an aqueous extract of Bai-Hua Qianhu, the root of Peucedanum praeruptorum DUNN. (Umbelliferae). Spectroscopic analysis and chemical studies were carried out to investigate the structure of the new coumarin, which was concluded to be 1. Additionally, two simple glycosidic coumarins and four simple nonglycosidic coumarins were identified as apiosylskimmin (2), hymexelsin (3), umbelliferone (4), scopoletin (5), isofraxidin (6) and 8-carboxy-7-hydroxy coumarin (7), respectively. This is the first reported identification of compound 7 as a constituent of plant materials.

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An apiose-containing coumarin glycoside from gmelina arborea root

Cited by 30 publications

References 6 publications

Toxicity study and analgesic activity of Gmelina arborea extract and its fractions

Toxicity study and analgesic activity of Gmelina arborea extract and its fractions

Coumarin Glycosides and Iridoid Glucosides with Neuroprotective Effects from Hydrangea paniculata

Studies of Coumarins from the Chinese Drug Qianhu, XXVII: Structure of a New Simple Coumarin Glycoside from Bai-Hua Qianhu, Peucedanum praeruptorum

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