An antioxidant suppressed lung cellular senescence and enhanced pulmonary function in aged mice

Kawaguchi, Koichiro; Hashimoto, Michihiro; Sugimoto, Masataka

doi:10.1016/j.bbrc.2020.12.112

Cited by 6 publications

(3 citation statements)

References 34 publications

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“… 265 Similarly, NAC attenuates aging-related oxidative damage and neurodegeneration in rat brains by upregulating sirtuin-1 and downregulating several SASP factors (TNF-α, IL-1β, IL-6). 266 In addition, NAC extends the lifespan of mice 267 and ameliorates a series of aging-related diseases in rodents, such as AD, 268 , 269 aortic fibrosis, 270 immunosenescence, 271 oxidative stress and senescence in the lung, 272 bone loss in ovariectomized mice, 273 adipose tissue senescence and metabolic abnormalities, 243 and aging-related hearing loss. 274 …”

Section: Epigenetic Regulation Of Agingmentioning

confidence: 99%

Epigenetic regulation of aging: implications for interventions of aging and diseases

Wang

Liu

et al. 2022

Sig Transduct Target Ther

151

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Aging is accompanied by the decline of organismal functions and a series of prominent hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic changes include DNA methylation, histone modification, chromatin remodeling, non-coding RNA (ncRNA) regulation, and RNA modification, all of which participate in the regulation of the aging process, and hence contribute to aging-related diseases. Therefore, understanding the epigenetic mechanisms in aging will provide new avenues to develop strategies to delay aging. Indeed, aging interventions based on manipulating epigenetic mechanisms have led to the alleviation of aging or the extension of the lifespan in animal models. Small molecule-based therapies and reprogramming strategies that enable epigenetic rejuvenation have been developed for ameliorating or reversing aging-related conditions. In addition, adopting health-promoting activities, such as caloric restriction, exercise, and calibrating circadian rhythm, has been demonstrated to delay aging. Furthermore, various clinical trials for aging intervention are ongoing, providing more evidence of the safety and efficacy of these therapies. Here, we review recent work on the epigenetic regulation of aging and outline the advances in intervention strategies for aging and age-associated diseases. A better understanding of the critical roles of epigenetics in the aging process will lead to more clinical advances in the prevention of human aging and therapy of aging-related diseases.

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Section: Epigenetic Regulation Of Agingmentioning

confidence: 99%

Epigenetic regulation of aging: implications for interventions of aging and diseases

Wang

Liu

et al. 2022

Sig Transduct Target Ther

151

View full text Add to dashboard Cite

show abstract

“…Gaining a point for demonstrating it targets several hallmarks of aging, NAC has been shown to decrease oxidative stress (only studied in conjunction with glycine), improve population doubling time of mesenchymal stem cells (only studied in conjunction with ascorbic acid), decrease the expression of senescence-associated genes, decrease mitochondrial dysfunction, and restore nutrient sensing. [73][74][75]…”

Section: Original Drugsmentioning

confidence: 99%

An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

Leone,

Barzilai

2024

MRAJ

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The biological mechanisms of aging drive the development of chronic diseases such as cardiovascular disease, diabetes, dementia, and cancer that dominate our current medical system. Geroscience-guided approaches seek to mitigate these pathological consequences of aging by targeting the fundamental hallmarks of aging. Using modalities that modulate these aging mechanisms to reinforce longevity we can prevent the onset of these diseases as well as target many of them at once. In this way, geroscience-guided approaches hope to extend both lifespan and healthspan in the near future. This article builds upon a previous paper which proposed a standardized process for evaluating FDA-approved medications for their geroscience potential and prioritized them to reflect preclinical and clinical evidence. In this article, we provide an update of the previous list of candidate gerotherapeutics to reflect the new and rapidly evolving evidence. We include the geroscience-guided evidence for three new FDA-approved drugs which did not have strong arguments for inclusion before: bisphosphonates, GLP-1 receptor agonists, beta blockers. This updated prioritization should help guide the efforts and financial investments for translating geroscience and allow immediate progress involving such candidate gerotherapeutics, especially the top 4 drugs: SGLT2 inhibitors, metformin, bisphosphonates, and GLP-1 receptor agonists. Since all of these drugs have been approved for safety and used extensively, repurposing them as gerotherapeutics should be considered in older adults.

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“…In vivo imaging ARF-DTR mice were anesthetized using 2% isoflurane (099-06571, Fuji Film) and 150 mg/kg body weight of luciferin (P1043, Promega) was intraperitoneally injected (Kawaguchi et al, 2021). Luciferase activity was monitored using the IVIS imaging system (Lumina II, Perkin Elmer).…”

Section: Declaration Of Interestsmentioning

confidence: 99%

Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production

et al. 2021

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Summary Cellular senescence acts as a potent tumor-suppression mechanism in mammals; however, it also promotes tumor progression in a non-cell-autonomous manner. We provided insights into the mechanism underlying senescence-dependent metastatic cancer development. The elimination of senescent cells suppressed the lung metastasis of melanoma cells. Using an antibody array screening of humoral factor(s) that depend on cellular senescence, we identified soluble E-cadherin (seCad) as a potential mediator of the senescence-induced melanoma metastasis. seCad enhanced the invasive activity of melanoma cells both in vitro and in vivo , and gene expression profiling revealed that seCad induced genes associated with poor prognosis in patients with melanoma. An analysis of sera from patients revealed that serum seCad is associated with distant metastasis. Our data suggest that senescent cells promote metastatic lung cancer through seCad, and that seCad may be a potential diagnostic marker as well as a therapeutic target for metastatic lung cancer.

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An antioxidant suppressed lung cellular senescence and enhanced pulmonary function in aged mice

Cited by 6 publications

References 34 publications

Epigenetic regulation of aging: implications for interventions of aging and diseases

Epigenetic regulation of aging: implications for interventions of aging and diseases

An Updated Prioritization of Geroscience- Guided FDA-Approved Drugs Repurposed to Target Aging

Cellular senescence promotes cancer metastasis by enhancing soluble E-cadherin production

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