An Antimicrobial Treatment Assessment of Serratia marcescens Bacteremia and Endocarditis

Slain, Douglas; Howard, Catessa; Cooper, C. Garret

doi:10.3389/frabi.2022.942721

Cited by 6 publications

(5 citation statements)

References 13 publications

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“…Notably, the highest resistance rate concerns the amoxicillin/clavulanic acid combination, probably due to the widespread use of this antibiotic in nosocomial settings. In accordance with our data, Slain et al demonstrated markedly elevated levels of resistance in strains of S. marcescens implicated in cases of bacteremia and endocarditis [17].…”

Section: Discussionsupporting

confidence: 93%

Current Epidemiological Status and Antibiotic Resistance Profile of Serratia marcescens

Cosimato,

Santella,

Rufolo

et al. 2024

Antibiotics

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The spread of antibiotic resistance represents a serious worldwide public health issue, underscoring the importance of epidemiology research in determining antimicrobial strategies. The purpose of this research was to investigate antibiotic resistance in Serratia marcescens isolates from clinical samples over seven years at the University Hospital “San Giovanni di Dio e Ruggi d’Aragona” in Salerno, Italy. S. marcescens is an important opportunistic pathogen associated with a wide spectrum of clinical diseases, including pneumonia, keratitis, meningitis, and urinary tract and wound infections. Outbreaks of nosocomial infections by S. marcescens strains have been documented in high-risk settings, mainly affecting immunocompromised patients and newborns. The primary objective of this study is to assess the rates of antibiotic resistance over the years to deal with a future emergency which includes the failure of various therapies due to antibiotic resistance. During the investigation, a total of 396 species of S. marcescens were isolated from various clinical samples, mainly from broncho-aspirates and sputum (31.6%) and blood cultures (21.5%). Antibiotics that showed the greatest susceptibility included ceftazidime/avibactam, amikacin, trimethoprim/sulfamethoxazole, and selected members of the cephalosporin class. However, a disconcerting trend of increasing rates of carbapenem resistance was outlined over the observation period. The absence of effective countermeasures, combined with growing antibiotic resistance that negates the effectiveness of multiple antibiotics, highlights the potential for S. marcescens infections to trigger serious clinical complications and increased mortality rates. The surveillance of Serratia marcescens infections constitutes a pivotal element in refining empiric therapy to mitigate the dissemination of antimicrobial resistance.

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Section: Discussionsupporting

confidence: 93%

Current Epidemiological Status and Antibiotic Resistance Profile of Serratia marcescens

Cosimato,

Santella,

Rufolo

et al. 2024

Antibiotics

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“…S. marcescens is a non-lactose fermenting, aerobic (facultative anaerobe), oxidase-negative, gram-negative bacillus organism ubiquitous to the environment and is found in soil, water, and plants. It is not a part of normal human flora [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

“…The patients with recurrences were treated with either a carbapenem or combination therapy. Seven patients died within 60 days of their first positive S. marcescens culture, attributable to comorbid conditions [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

Serratia marcescens Endocarditis in Prosthetic Valves

Jamil,

Sharma,

Ali

et al. 2023

Cureus

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Serratia marcescens endocarditis is a rare occurrence. We describe a case of Serratia endocarditis in a patient with a prosthetic valve. The clinical course was complicated by widespread embolic phenomena causing stroke, gangrene of extremities, and septic emboli to the lungs, spleen, and eyes. She was not considered suitable for surgery due to severe consumptive coagulopathy and thrombocytopenia in the setting of widespread emboli. The patient was transitioned to do not resuscitate status and discharged to a long-term care facility with a grave prognosis explained to the family.

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“…Future research in this area should prioritize obtaining larger sample sizes to overcome this limitation and provide more comprehensive insights into the subject matter such as the inclusion of an experimentally induced infection with the isolates in T. molitor . Despite this limitation, we consider the S. marcescens isolated from T. molitor as a potential pathogenic bacterium associated with human infections, i.e., a bacterial species with zoonotic potential [ 14 , 16 ]. Moreover, S. marcescens is known as an opportunistic bacterial pathogen of insects, poultry, fish, and calves.…”

Section: Discussionmentioning

confidence: 99%

“…S. marcescens is a Gram-negative motile Proteobacteria, a member of the order Enterobacterales, commonly associated with opportunistic infections in humans, and in various animal species [ 13 , 14 ]. In humans, the bacterium has been described to cause diarrhea in children in low-income countries [ 15 ], endocarditis, sepsis, infections of prosthetic heart valves [ 16 ], and nosocomial infections, whereby both hand-to-nose contact (contact zoonosis) and ingestion of the bacterium (food zoonosis) may infect humans [ 17 , 18 , 19 ]. In poultry [ 20 , 21 ], S. marcescens is considered to be a commensal respiratory bacterium.…”

Section: Introductionmentioning

confidence: 99%

Molecular Characterization of Serratia marcescens Strain Isolated from Yellow Mealworms, Tenebrio molitor, in The Netherlands

Bello Gonzalez,

van Gelderen,

Harders

et al. 2023

Insects

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Insect culture has developed rapidly worldwide; it faces important security and safety control issues, including animal infections and disease development. In the Netherlands, in 2021, a ~30% mortality of mealworms, Tenebrio molitor, occurred at one farm, where over-humid sites in the substrate were observed. Bacterial cultures from both the external and internal partsof fry and larger mealworms were identified by MALDI-TOF to predominantly Serratia marcescens, Staphylococcus xylosus and Staphylococus saprofyticus. Due to the important role of S. marcescens as a potential zoonotic bacterium, we performed a molecular characterization of the isolated strain. Genomic analysis showed a multidrug-resistant S. marcescens isolate carrying a tet (41), aac (6′)-Ic, and blaSST-1 chromosomal class C beta-lactamase-resistantgenes, all located on the chromosome. Additionally, several virulence genes were identified. The phylogenetic tree revealed that the S. marcescens strain from this study was similar to other S. marcescens strains from different ecological niches. Although the entomopathogenic activity was not confirmed, this case demonstrates that T. molitor can act as a reservoir and as an alternative path for exposing clinically important antibiotic-resistant bacteria that can affect animals and humans. It underlines the need to keep management factors optimal, before insects and their products enter the feed and food chain.

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An Antimicrobial Treatment Assessment of Serratia marcescens Bacteremia and Endocarditis

Cited by 6 publications

References 13 publications

Current Epidemiological Status and Antibiotic Resistance Profile of Serratia marcescens

Current Epidemiological Status and Antibiotic Resistance Profile of Serratia marcescens

Serratia marcescens Endocarditis in Prosthetic Valves

Molecular Characterization of Serratia marcescens Strain Isolated from Yellow Mealworms, Tenebrio molitor, in The Netherlands

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