An antifungal γ-pyrone and xanthones with monoamine oxidase inhibitory activity from Hypericum brasiliense

Rocha, Leandro; Marston, Andrew; Auxiliadora, María; Kaplan, Coelho; Stœckli-Evans, Helen; Thull, Ulrike; Testa, Bernard; Hostettmann, Kurt

doi:10.1016/s0031-9422(00)89727-7

Cited by 119 publications

(60 citation statements)

References 18 publications

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“…The study leadered by Healy et al (2004) resulted on the isolation of xanthones, compounds isolated from endophytic fungi identified as Xylaria sp. The fungus isolated from Glochidion ferdinandi plant, and the metabolites extracted showed important pharmacological activities (Peres & Nagem, 1996;Peres et al, 2000) as for example, anti-inflammatory (Lin et al, 1996), antimicrobial (Malet-Cascon et al, 2003), antioxidants (Minami et al, 1994), antifungical (Rocha et al, 1994) e anticancer properties (Ho et al, 2002). Krohn et al (2004), developed an similar research, describing the syntesis of xyloketal D, a natural product that belongs to a group of secondary metabolites isolated from Xylaria sp.…”

Section: Xylariaceae Metabolites Biological Activitymentioning

confidence: 99%

Xylariaceae Endophytic Fungi Metabolites Against Salmonella

Ribeiro¹,

Fonseca²,

Reis³

et al. 2012

Salmonella - A Diversified Superbug

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Section: Xylariaceae Metabolites Biological Activitymentioning

confidence: 99%

Xylariaceae Endophytic Fungi Metabolites Against Salmonella

Ribeiro¹,

Fonseca²,

Reis³

et al. 2012

Salmonella - A Diversified Superbug

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“…Although Hypericum perforatum L. is the most studied species of the genus, some studies also included Hypericum brasiliense Choisy as a source of the same secondary metabolites and medicinal proprieties related to H. perforatum (Rocha et al 1994, Abreu et al 2004. To increase the knowledge of this Brazilian native species, several aspects of its biology are required to be studied, such as reproductive biology and cytology.…”

Section: Introductionmentioning

confidence: 99%

Reproductive biology and cytology of Hypericum brasiliense Choisy (Hypericaceae)

Moraes¹,

Pinto-Maglio²,

Lombello³

2009

Rev. bras. Bot.

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-(Reproductive biology and cytology of Hypericum brasiliense Choisy (Hypericaceae)). This is the fi rst study of reproductive biology and cytology carried out with Hypericum brasiliense, a species with medicinal properties and potential agronomic interest. Three populations of H. brasiliense collected at Southeastern Brazil were studied. The results indicate that H. brasiliense is preferentially allogamous, self-compatible, facultative apomitic and anemophilous. Male sterility was observed in about 50% of individuals from the three populations. Anatomical studies evidenced structural abnormalities in anthers of male sterile fl owers, showing enlarged tapetal cells and thick secretion deposits on the tapetal cell surfaces that may cause nutritional defi cit for pollen mother cells. In cytogenetic studies several haploid chromosome numbers were observed like n = 4, 8, 9, 11, 16 and 17, including the presence of multivalents and micronuclei in tetrads, indicating the occurrence of abnormalities in the meiotic process of H. brasiliense. Despite these meiotic abnormalities the pollen viability and in vitro pollen germination rate observed in fertile fl owers may be considered high. The diploid chromosome number 2n = 16 was observed, and the chromosomes in metaphase were small and similar. Fluorochrome staining techniques using DAPI and CMA 3 were applied, with no positive bands observed.Key words -anatomy of anthers, apomixy, irregular meiosis, male sterility RESUMO -(Biologia da reprodução e citologia de Hypericum brasiliense Choisy (Hypericaceae)). Este é o primeiro estudo de biologia da reprodução e citologia realizado em Hypericum brasiliense, uma espécie com propriedades medicinais e de interesse agronômico. Três populações de H. brasiliense da região Sudeste do Brasil foram estudadas. Os resultados obtidos dos estudos indicam que H. brasiliense é uma espécie preferencialmente alógama, auto-compatível, apomítica facultativa e anemófi la. Foi observada macho-esterilidade em 50% dos indivíduos estudados nas três populações. Estudos anatômicos evidenciaram anormalidades estruturais nas anteras de fl ores macho-estéreis, como células do tapete aumentadas, com grossas camadas de secreções depositadas em sua superfície que podem originar defi ciências nutricionais para as células mães do pólen. Nos estudos citogenéticos diversos números haplóides foram observados, tais como n = 4, 8, 9, 11, 16 e 17, incluindo a presença de multivalentes e micronúcleos em tétrades, indicando a ocorrência de anormalidades no processo meiótico de H. brasiliense. Apesar das anormalidades meióticas a viabilidade polínica e o índice de germinação in vitro dos pólens observado para as fl ores férteis podem ser considerados altos. O número cromossômico diplóide registrado foi 2n = 16, com cromossomos metafásicos pequenos e similares entre si. Foram aplicadas técnicas de bandamento com fl uorocromos DAPI e CMA 3 , sem que bandas positivas fossem observadas.Palavras-chave -anatomia de anteras, apomixia, irregularidade meiótica, macho-e...

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“…Reported biological activities included anticancer (Ho et al, 2002), antifungal (Rocha et al, 1994), antioxidant (Minami et al, 1994) antimicrobial (Malet-Cascon et al, 2003), antiinflammatory (Lin et al, 1996) and antiviral (Groweiss et al, 2000). The majority of xanthones reported in the literature have been isolated from higher plants, especially those belonging to the families Gentianaceae and Clusiaceae (Peres and Nagem, 1996;Peres et al, 2000).…”

Section: Introductionmentioning

confidence: 99%

Xanthones from a Microfungus of the Genus Xylaria.

et al. 2005

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Chemical investigations of a microfungus Xylaria sp. isolated from the Australian rainforest tree Glochidion ferdinandi have afforded two new natural products, 2-hydroxy-6-methyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (1) and 2-hydroxy-6-hydroxymethyl-8-methoxy-9-oxo-9H-xanthene-1-carboxylic acid (2). Compound 1 has previously been synthesised but only partially characterised. Methylation of 1 using diazomethane afforded the crystalline compound 2,8-dimethoxy-6-methyl-9-oxo-9H-xanthene-1-carboxylic acid methyl ester (3), whose structure was determined by single crystal X-ray analysis. This paper reports the full spectroscopic characterisation of compounds 1-3 by NMR, UV, IR and MS data. All compounds were inactive in a brine shrimp lethality assay and several antimicrobial screens.

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An antifungal γ-pyrone and xanthones with monoamine oxidase inhibitory activity from Hypericum brasiliense

Cited by 119 publications

References 18 publications

Xylariaceae Endophytic Fungi Metabolites Against Salmonella

Xylariaceae Endophytic Fungi Metabolites Against Salmonella

Reproductive biology and cytology of Hypericum brasiliense Choisy (Hypericaceae)

Xanthones from a Microfungus of the Genus Xylaria.

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