An antidysrhythmic agent.

Oram, S; Catley, P F; Livesley, Brian; Kidner, P. H.

doi:10.1136/bmj.4.5779.113-a

Cited by 5 publications

(2 citation statements)

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“…Oram et al (1971) have recorded a reversion of an Atropine-induced tachycardia with Verapamil. Our results suggest that any vagal effect is minor and that its principal mode of action is via an intrinsic effect on the atrio-ventricular node.…”

Section: Discussionmentioning

confidence: 99%

The effect of Verapamil on the cardiac conduction system in man

Roy

Spurrell

Sowton

1974

Postgraduate Medical Journal

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SummaryUsing His bundle electrograms the effect of Verapamil on the specialized conduction system in eleven patients was studied during routine cardiac catheterization.In five patients, the absolute and relative refractory periods of the A-V node, and retrograde conduction through the A-V node was studied using programmed electrical stimulation techniques.Verapamil caused prolongation of anterograde and retrograde A-V nodal conduction times. The effect on anterograde conduction was only partly reversible with Atropine. No significant effect on the remainder of the conduction system was observed.It is concluded that Verapamil has a direct effect on A-V nodal conduction independent of any vagotonic effect.

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Section: Discussionmentioning

confidence: 99%

The effect of Verapamil on the cardiac conduction system in man

Roy

Spurrell

Sowton

1974

Postgraduate Medical Journal

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“…Its exact mode of action is not known, but it can abolish the tachycardia induced by both isoprenaline and atropine (Oram et al, 1971). Certainly verapamil does not act solely as a beta-blocker (Ross and Jorgensen, 1967), nor does it have a quinidine-like action (Singh and Vaughan-Williams, 1972).…”

Section: Introductionmentioning

confidence: 99%

Double-blind Evaluation of Verapamil, Propranolol, and Isosorbide Dinitrate against a Placebo in the Treatment of Angina Pectoris

Livesley¹,

Catley²,

Campbell³

et al. 1973

BMJ

173

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SummaryIn the treatment of angina pectoris a double-blind evaluation of verapamil (Cordilox) at two dose levelsnamely, 80 mg thrice daily and 120 mg thrice dailypropranolol (Inderal) 100 mg thrice daily, and isosorbide dinitrate (Vascardin) 20 mg thrice daily has been made against a placebo. The assessment was based on relief from daily attacks of angina on effort and the response to a whole-body exercise test. We can find no statistically significant difference between the effects of verapamil (120 mg three times a day) and propranolol (100 mg three times a day) in the treatment of angina of effort. Both of these preparations are more effective than a placebo both in the reduction of daily attacks (P < 0-01) and in the prolongation of exercise test (P < 005). Isosorbide dinitrate (20 mg three times a day) appears to be no more effective than a placebo in the treatment of angina on effort, but 14 out of 32 patients experienced headache of such severity that even when the dose was reduced to 10 mg thrice daily this drug therapy had to be withdrawn. Both propranolol (100 mg three times a day) and verapamil (120 mg-three times a day) had a significant lowering effect on the diastolic blood pressure as measured with the patient standing (P < 0-01).

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Wirkungsspektrum der Calciumantagonisten

Nawrath¹

1983

Herzrhythmusstörungen

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An antidysrhythmic agent.

Cited by 5 publications

References 0 publications

The effect of Verapamil on the cardiac conduction system in man

The effect of Verapamil on the cardiac conduction system in man

Double-blind Evaluation of Verapamil, Propranolol, and Isosorbide Dinitrate against a Placebo in the Treatment of Angina Pectoris

Wirkungsspektrum der Calciumantagonisten

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