An Antibody in the Serum of an MN Patient which Reacts with the M(1) Antigen

Abstract

Three atypical saline agglutinins were found in a serum and were identified as anti-Vw, anti-Bp^a and anti-M(1). The patient is MN and the anti-M(1) is the first example to be found in the absence of anti-M. The M(1) antigen was present in 16.7% of Negro M-positive samples. One M(1)N S-s-U- sample was also detected.

MNS Blood Group System

“…At the appropriate pH and dilution these sera behaved as anti -M 1 and, with these sera, 24% of African Americans were found to be M 1 + [87,188] . Two examples of anti -M 1 from M + N + individuals provided somewhat lower frequencies for M 1 antigen: 17% of black people and less than 1% of white people were M 1 + [423,429] (Table 3. Table 3.12 shows the frequencies of antigens detected by these antibodies, which form the 213, MN CHO, Collection of the ISBT terminology [425] .…”