An anti-steroidogenic inhibitory primer pheromone in male sea lamprey (Petromyzon marinus)

Chung-Davidson, Yu Wen; Wang, Jianji; Bryan, Mara B.; Wu, Hong; Johnson, Nicholas S.; Li, Weiming

doi:10.1016/j.ygcen.2013.04.023

Cited by 16 publications

(9 citation statements)

References 55 publications

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“…Migratory sea lamprey are acutely tuned to the larval odor ( migratory cue ); putative components are detected at low concentrations [ 50 ] and larval odor elicits behavioral responses at the concentrations produced by a single larvae diluted several thousand fold [ 51 ]. Once sea lamprey arrive at the spawning grounds, final sexual maturation is partially triggered by conspecific odors [ 52 , 53 ]. Upon complete sexual maturation, mate search and spawning are guided by the odors of the opposite sex [ 11 ].…”

Section: Chemical Cueing and Pheromone Communication In Sea Lampreymentioning

confidence: 99%

“…A bile acid structurally similar to 3kPZS but lacking in the C24 sulfate, 3 keto allocholic acid (3kACA) was hypothesized to function as an additional component [ 64 , 80 , 81 ], but has now been resolved behaviorally inactive [ 56 ]. Notably, sea lamprey detect 3kACA with high sensitivity and specificity [ 64 ], and steroidogenesis in males is inhibited by exposure to 3kACA [ 53 ]. A 4 oxidized, unsaturated compound similar to 3kPZS elicited attraction in females [ 82 ].…”

Section: Migratory Cues and Mating Pheromonesmentioning

confidence: 99%

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Chemical cues and pheromones in the sea lamprey (Petromyzon marinus)

et al. 2015

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Chemical cues and pheromones guide decisions in organisms throughout the animal kingdom. The neurobiology, function, and evolution of olfaction are particularly well described in insects, and resulting concepts have driven novel approaches to pest control. However, aside from several exceptions, the olfactory biology of vertebrates remains poorly understood. One exception is the sea lamprey (Petromyzon marinus), which relies heavily upon olfaction during reproduction. Here, we provide a broad review of the chemical cues and pheromones used by the sea lamprey during reproduction, including overviews of the sea lamprey olfactory system, chemical cues and pheromones, and potential applications to population management. The critical role of olfaction in mediating the sea lamprey life cycle is evident by a well-developed olfactory system. Sea lamprey use chemical cues and pheromones to identify productive spawning habitat, coordinate spawning behaviors, and avoid risk. Manipulation of olfactory biology offers opportunities for management of populations in the Laurentian Great Lakes, where the sea lamprey is a destructive invader. We suggest that the sea lamprey is a broadly useful organism with which to study vertebrate olfaction because of its simple but well-developed olfactory organ, the dominant role of olfaction in guiding behaviors during reproduction, and the direct implications for vertebrate pest management.

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Section: Chemical Cueing and Pheromone Communication In Sea Lampreymentioning

confidence: 99%

Section: Migratory Cues and Mating Pheromonesmentioning

confidence: 99%

Chemical cues and pheromones in the sea lamprey (Petromyzon marinus)

et al. 2015

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“…10). 3KPZS and 3KACA have been shown to help elicit sexual maturation in both males and females (Chung-Davidson et al, 2013a, b) thus synchronizing the reproductive state of conspecifics. 3kPZS also has a behavioural function, inducing upstream swimming in sexually mature females (Li et al, 2002; Siefkes et al, 2005; Johnson et al, 2009) to aid them in finding nesting males, and eliciting nest construction and pair maintenance behaviours (Johnson et al, 2012) to coordinate the final act of reproduction.…”

Section: Emerging Control Tacticsmentioning

confidence: 99%

Use of physiological knowledge to control the invasive sea lamprey (Petromyzon marinus) in the Laurentian Great Lakes

Siefkes

2017

Conservation Physiology

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“…1D) [16]. An analogous allo – or 5α – epimer corresponding to every “typical” 5β bile acid molecule has been observed in nature and are usually found in less evolved species: for example, a version of allo -cholic acid is a primary BA and pheromone in sea lamprey [17]. The other type of flat BAs are those with a double bond between the C4 and C5 atoms, trivially called the Δ 4 -unsaturated BAs (Fig.…”

Section: Chemical Characterization Of ‘Flat’ Basmentioning

confidence: 99%

Planar bile acids in health and disease

Shiffka

Kane

Swaan

2017

Biochimica et Biophysica Acta (BBA) - Biomembranes

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Bile acids are the amphipathic primary end-products of cholesterol metabolism that aid in digestion as well as participate in signal transduction in several hepatic and enteric pathways. Despite the reputation of bile acids as signaling molecules implicated in disease states such as cancer and diabetes, there remain numerous bile acid species that are weakly characterized in either physiological or pathological conditions. This review presents one such group: the flat or planar bile acids, a set of bile acids found in humans during infancy and occurring again during certain diseases. As their name implies, these molecules are structurally distinct from the typical human bile acids, retaining the planar structure of their cholesterol predecessor instead of bending or twisting at the A ring. This review defines these species of bile acids in detail and describes their presence in infancy, gestation, and in disease. The large gaps in research regarding the flat bile acids are highlighted and all available experimental knowledge collected as far as 60 years ago is summarized. Further, the potential for these molecules as endogenous biomarkers of liver disease and injury is discussed. Finally, the flat bile salts found in humans are compared to the ancestral and evolutionary older bile salts, which similarly have a flat steroidal structure, as mechanisms of flat bile acid biosynthesis are explored.

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An anti-steroidogenic inhibitory primer pheromone in male sea lamprey (Petromyzon marinus)

Cited by 16 publications

References 55 publications

Chemical cues and pheromones in the sea lamprey (Petromyzon marinus)

Chemical cues and pheromones in the sea lamprey (Petromyzon marinus)

Use of physiological knowledge to control the invasive sea lamprey (Petromyzon marinus) in the Laurentian Great Lakes

Planar bile acids in health and disease

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