An anti-bacterial monoclonal antibody that targets pathogenic bacteria expressing the type 3 secretion system for therapeutic and diagnostic applications
Abstract:It is predicted that failure to address the antibiotic-resistance crisis will result in an annual death rate of 10 million people by the year 2050. To grapple with the challenges of the impending crisis, there is an urgent need for novel anti-bacterial agents and rapid diagnostic tools. Here, we developed a novel monoclonal antibody-known as mAb-EspB-B7-that targets EspB, a component within the bacterial type 3 secretion system (T3SS), which is mainly expressed in Gram-negative pathogens and is essential for b… Show more
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