An anti-bacterial and anti-cancer fibrous membrane with multiple therapeutic effects for prevention of pancreatic cancer recurrence

Zhang, Qiang; Luo, Yang; Liu, Bo; Suo, Di; Lv, Shang; Wang, Yi; Zhao, Xin

doi:10.1016/j.bioadv.2022.212831

Cited by 8 publications

(7 citation statements)

References 44 publications

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“…After the development of MEHP, we further fabricated the PLLA fibrous membrane to build the Janus patch. ,, First, PLLA (Mw = 10 kDa, Jinan Daigang Co., Jinan, China) was dissolved in hexafluoro-2-propanol by a magnetic stirrer to prepare the PLLA precursor solution (20% w/v). Then, electrospinning with a 15 kV applied voltage was performed while setting the flow rate as 1 mL/h and the working distance as 10 cm.…”

Section: Experimental Methodsmentioning

confidence: 99%

“…Currently, systemic and in situ applications of corticosteroid and nonsteroidal anti-inflammatory drugs after tendon surgery have been prescribed to decrease the inflammatory reaction and relieve postoperative pain, despite of the side effects upon prolonged administration of the drugs. , Besides, another concern is the inability to provide local protection for the operated tendon . With the advancement of tissue engineering, fibrous membranes fabricated by electrospinning have received increasing attention since they possess high aspect ratios, biomimetic extracellular matrix (ECM) structures, excellent physical strength, and drug carrying capabilities, which can work as a suitable physical barrier to treat tendon injuries. − For example, Zhang et al prepared a curcumin/celecoxib-loaded electrospun membrane, which could be triggered by the oxidative stress of the local microenvironment to release drugs for preventing peritendinous adhesion . Most recently, Xiang et al constructed a versatile gene delivery platform by combining a polyethylene glycol-based polyester hydrogel with a poly(lactic- co -glycolic acid) electrospun membrane .…”

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confidence: 99%

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A Biomimetic Adhesive and Robust Janus Patch with Anti-Oxidative, Anti-Inflammatory, and Anti-Bacterial Activities for Tendon Repair

Zhang,

Yang,

Suo

et al. 2023

ACS Nano

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Early stage oxidative stress, inflammatory response, and infection after tendon surgery are highly associated with the subsequent peritendinous adhesion formation, which may diminish the quality and function of the repaired tendon. Although various anti-inflammatory and/or antibacterial grafts have been proposed to turn the scale, most of them suffer from the uncertainty of drug-induced adverse effects, low mechanical strength, and tissue adhesiveness. Here, inspired by the tendon anatomy and pathophysiology of adhesion development, an adhesive and robust dual-layer Janus patch is developed, whose inner layer facing the operated tendon is a multifunctional electrospun hydrogel patch (MEHP), encircled further by a poly-L-lactic acid (PLLA) fibrous outer layer facing the surrounding tissue. Specifically, MEHP is prepared by gelatin methacryloyl (GelMA) and zinc oxide (ZnO) nanoparticles, which are co-electrospun first and then treated by tannic acid (TA). The inner MEHP exhibits superior mechanical performance, adhesion strength, and outstanding antioxidation, anti-inflammation, and antibacterial properties, and it can adhere to the injury site offering a favorable microenvironment for tendon regeneration. Meanwhile, the outer PLLA acts as a physical barrier that prevents extrinsic cells and tissues from invading the defect site, reducing peritendinous adhesion formation. This work presents a proof-of-concept of a drug-free graft with anisotropic adhesive and biological functions to concert the healing phases of injured tendon by alleviating incipient inflammation and oxidative damage but supporting tissue regeneration and reducing tendon adhesion in the later phase of repair and remodeling. It is envisioned that this Janus patch could offer a promising strategy for safe and efficient tendon therapy.

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Section: Experimental Methodsmentioning

confidence: 99%

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confidence: 99%

A Biomimetic Adhesive and Robust Janus Patch with Anti-Oxidative, Anti-Inflammatory, and Anti-Bacterial Activities for Tendon Repair

Zhang,

Yang,

Suo

et al. 2023

ACS Nano

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“…Xin Zhao et al fused antibacterial and antitumour effects in a fibrous membrane (AAFM) to target common drug-resistant γ-amoebacteria ( Gammaproteobacteria ). 75 The main body of this fibrous membrane was prepared by electrospinning GEM and poly- l -lactic acid (PLLA), followed by a two-step impregnation of tannic acid (TA) and silver nanoparticles (AgNPs) on electrospun fibers. The AAFM showed a good antimicrobial activity of up to 80%, suggesting the antimicrobial effect exerted by AgNPs.…”

Section: Drug Delivery Systems For Intra-tumoral Bacterial Therapymentioning

confidence: 99%

Drug delivery systems for enhanced tumour treatment by eliminating intra-tumoral bacteria

Liu,

Ma,

et al. 2024

J. Mater. Chem. B

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“…Zhang et al developed a fiber scaffold that included an anticancer agent and an antibacterial agent for the prevention of cancer recurrence [ 228 ] ( Figure 22 ). To fabricate this scaffold, an anticancer agent GEM-loaded fibrous membrane was first prepared by electrospinning by blending GEM with poly-L-lactic acid (PLLA).…”

Section: Biomedical Applications Of the Therapeutic Agent-loaded Fibr...mentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

Therapeutic Agent-Loaded Fibrous Scaffolds for Biomedical Applications

et al. 2023

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Tissue engineering is a sophisticated field that involves the integration of various disciplines, such as clinical medicine, material science, and life science, to repair or regenerate damaged tissues and organs. To achieve the successful regeneration of damaged or diseased tissues, it is necessary to fabricate biomimetic scaffolds that provide structural support to the surrounding cells and tissues. Fibrous scaffolds loaded with therapeutic agents have shown considerable potential in tissue engineering. In this comprehensive review, we examine various methods for fabricating bioactive molecule-loaded fibrous scaffolds, including preparation methods for fibrous scaffolds and drug-loading techniques. Additionally, we delved into the recent biomedical applications of these scaffolds, such as tissue regeneration, inhibition of tumor recurrence, and immunomodulation. The aim of this review is to discuss the latest research trends in fibrous scaffold manufacturing methods, materials, drug-loading methods with parameter information, and therapeutic applications with the goal of contributing to the development of new technologies or improvements to existing ones.

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An anti-bacterial and anti-cancer fibrous membrane with multiple therapeutic effects for prevention of pancreatic cancer recurrence

Cited by 8 publications

References 44 publications

A Biomimetic Adhesive and Robust Janus Patch with Anti-Oxidative, Anti-Inflammatory, and Anti-Bacterial Activities for Tendon Repair

A Biomimetic Adhesive and Robust Janus Patch with Anti-Oxidative, Anti-Inflammatory, and Anti-Bacterial Activities for Tendon Repair

Drug delivery systems for enhanced tumour treatment by eliminating intra-tumoral bacteria

Therapeutic Agent-Loaded Fibrous Scaffolds for Biomedical Applications

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