An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1<sup>G93A</sup> mouse model of amyotrophic lateral sclerosis

Winter, Aimee N.; Ross, Erika; Wilkins, Heather; Stankiewicz, Trisha R.; Wallace, Tyler; Miller, Keith E.; Linseman, Daniel A.

doi:10.1080/1028415x.2017.1297023

Cited by 37 publications

(20 citation statements)

References 57 publications

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“…Anthocyanins are polyphenolic flavonoids widely found in fruits, flowers, grains, and vegetables [ 94 ]. This flavonoid has antioxidant, anti-inflammatory, and antiapoptosis properties, in addition to improving memory and cognition [ 95 ]. They are characterized by the basic flavylium core (2-phenylbenzopyryl cation) consisting of two aromatic rings joined by a three-carbon unit and condensed by an oxygen.…”

Section: Resultsmentioning

confidence: 99%

Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences

Teles

Diniz

Pinto

et al. 2018

Oxidative Medicine and Cellular Longevity

139

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Alzheimer's and Parkinson's diseases are considered the most common neurodegenerative disorders, representing a major focus of neuroscience research to understanding the cellular alterations and pathophysiological mechanisms involved. Several natural products, including flavonoids, are considered able to cross the blood-brain barrier and are known for their central nervous system-related activity. Therefore, studies are being conducted with these chemical constituents to analyze their activities in slowing down the progression of neurodegenerative diseases. The present systematic review summarizes the pharmacological effects of flavonoids in animal models for Alzheimer's and Parkinson's diseases. A PRISMA model for systematic review was utilized for this search. The research was conducted in the following databases: PubMed, Web of Science, BIREME, and Science Direct. Based on the inclusion criteria, 31 articles were selected and discussed in this review. The studies listed revealed that the main targets of action for Alzheimer's disease therapy were reduction of reactive oxygen species and amyloid beta-protein production, while for Parkinson's disease reduction of the cellular oxidative potential and the activation of mechanisms of neuronal death. Results showed that a variety of flavonoids is being studied and can be promising for the development of new drugs to treat neurodegenerative diseases. Moreover, it was possible to verify that there is a lack of translational research and clinical evidence of these promising compounds.

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Section: Resultsmentioning

confidence: 99%

Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences

Teles

Diniz

Pinto

et al. 2018

Oxidative Medicine and Cellular Longevity

139

View full text Add to dashboard Cite

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“…Anthocyanin derived from strawberries possesses anti-oxidative, anti-inflammatory, and anti-apoptotic abilities. It has been reported to alleviate astrogliosis and preserve neuromuscular junctions and muscle function, serving as a possible therapeutic agent for ALS and other neurodegenerative diseases ( Winter et al, 2017 ). During AD progression, resveratrol’s potential in protecting neurons from Aβ and OS-induced toxicity shows promising therapeutic applications ( Anekonda, 2006 ; Bellaver et al, 2014 ).…”

Section: Oxidative Stress and Nutritional Status In Neurodegenerativementioning

confidence: 99%

Role of ROS and Nutritional Antioxidants in Human Diseases

et al. 2018

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The overproduction of reactive oxygen species (ROS) has been implicated in the development of various chronic and degenerative diseases such as cancer, respiratory, neurodegenerative, and digestive diseases. Under physiological conditions, the concentrations of ROS are subtlety regulated by antioxidants, which can be either generated endogenously or externally supplemented. A combination of antioxidant-deficiency and malnutrition may render individuals more vulnerable to oxidative stress, thereby increasing the risk of cancer occurrence. In addition, antioxidant defense can be overwhelmed during sustained inflammation such as in chronic obstructive pulmonary diseases, inflammatory bowel disease, and neurodegenerative disorders, cardiovascular diseases, and aging. Certain antioxidant vitamins, such as vitamin D, are essential in regulating biochemical pathways that lead to the proper functioning of the organs. Antioxidant supplementation has been shown to attenuate endogenous antioxidant depletion thus alleviating associated oxidative damage in some clinical research. However, some results indicate that antioxidants exert no favorable effects on disease control. Thus, more studies are warranted to investigate the complicated interactions between ROS and different types of antioxidants for restoration of the redox balance under pathologic conditions. This review highlights the potential roles of ROS and nutritional antioxidants in the pathogenesis of several redox imbalance-related diseases and the attenuation of oxidative stress-induced damages.

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“…Only one study assessed the potential of ACNs in preventing the onset and progression of ALS, characterized by loss of motor neurons in brain, brainstem and spinal cord (Winter et al, 2018). Oral administration of an ACN-rich extract from strawberries in a mouse model of ALS, carrying a G93A mutation in the human SOD1 gene (hSOD1 G93A ), modestly but significantly delayed the onset of ALS (about 17 days) and extended the survival (about 11 days) when to untreated hSOD1 G93A mice, in which ALS onset occurred at about 90 days of age and progress to end-stage of disease at about 120 days age.…”

Section: Mechanistic and Molecular Aspects Of Neuroprotective Effectsmentioning

confidence: 99%

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

et al. 2020

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Anthocyanins are natural phenolic pigments with biological activity. They are well-known to have potent antioxidant and antiinflammatory activity, which explains the various biological effects reported for these substances suggesting their antidiabetic and anticancer activities, and their role in cardiovascular and neuroprotective prevention. This review aims to comprehensively analyze different studies performed on this class of compounds, their bioavailability and their therapeutic potential. An in-depth look in preclinical, in vitro and in vivo, and clinical studies indicates the preventive effects of anthocyanins on cardioprotection, neuroprotection, antiobesity as well as their antidiabetes and anticancer effects.

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An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis

Cited by 37 publications

References 57 publications

Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences

Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences

Role of ROS and Nutritional Antioxidants in Human Diseases

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

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An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis

Cited by 37 publications

References 57 publications

Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences

Flavonoids as Therapeutic Agents in Alzheimer’s and Parkinson’s Diseases: A Systematic Review of Preclinical Evidences

Role of ROS and Nutritional Antioxidants in Human Diseases

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

Contact Info

Product

Resources

About

An anthocyanin-enriched extract from strawberries delays disease onset and extends survival in the hSOD1^G93A mouse model of amyotrophic lateral sclerosis