AN ANSWER TO THE SPIRO VS ANSA DILEMMA IN CYCLOPHOSPHAZENES. PART VIII. THE FIRST FUSED DISPIROCYCLOTRIPHOSPHAZENES, N₃P₃CL₂[HN[sbnd](CH₂)_m[sbnd]NH] [HN[sbnd](CH₂)_N[sbnd]NH](m ≠ n = 2,3,4)

Abstract

1985) AN ANSWER TO THE SPIRO VS ANSA DILEMMA IN CYCLOPHOSPHAZENES. PART VIII. THE FIRST FUSED DISPIROCYCLOTRIPHOSPHAZENES, N 3 P 3 CL 2 [HN[sbnd](CH 2 ) m [sbnd]NH] [HN[sbnd] (CH 2 ) N [sbnd]NH](m ≠ n = 2,3,4), Phosphorus and Sulfur and the Related Elements, 25:3, 273-287, AN ANSWER TO THE SPIRO VS ANSA DILEMMA IN CYCLOPHOSPHAZENES. PART VIII*. THE FIRST FUSED DISPIROCY CLOTRIPHOSPHAZENES, [HN-(CH2)n-NH](m f n = 2,3,4). The synthesis of the first fused DISPIROcyclotriphosphazenes was achieved upon reaction of a diamine H,N-(CH,)m-NH, (,with m = 2.3,4) on the N,P,CI,[HN-(CH2),-NH2](with n # m ) MONOSPIRO derivative in stoichiometric conditions. Molecular structures were ascribed by using both P and I H high resolution NMR and electron-impact mass spectrometry. The chemical shift of the phosphorus atoms bearing the loop varies linearly with the value of the corresponding NPN endocyclic angle. The synthesis of this fused derivatives occurs in quantitative yield. It leads the way for the covalent binding at demand on a cyclophosphazene antitumoral system of several natural polyamines as tumor finders in the SPIRO configuration.

Phosphorus–nitrogen compounds: part 68. Synthesis, characterization, stereogenism, photophysical and bioactivity studies of novel unsymmetrical dispiro(N/N)cyclotriphosphazenes with carbazolyl and 4-chlorobenzyl pendant arms

“…However, in the literature, there are very few studies on unsymmetrical dispirocyclotriphosphazenes without pendant arms. 20,47–50 Moreover, to the best of our knowledge, there is no paper dealing with dispirocyclotriphosphazenes containing different spiro-rings with different unsymmetrical pendant arms.…”

“…However, in the literature, there are very few studies on unsymmetrical dispirocyclotriphosphazenes without pendant arms. 20,[47][48][49][50] Fig. 1 The expected chiral isomer distributions of the cis and trans dispirophosphazenes.…”

Phosphorus-nitrogen compounds: Part 69—Unsymmetrical dispiro(N/N)cyclotriphosphazenes containing different pendant arms: syntheses, characterization, stereogenism, photophysical and bioactivity studies

“…A literature survey revealed that there are quite a number of manuscripts on symmetrically substituted dispirocyclotriphosphazenes [14,16,22,23]. However, there are a few studies on unsymmetrical dispirocyclotriphosphazenes without pendant arms in the literature [44][45][46][47]. Moreover, to the best of our knowledge, there is not any report dealing with dispirocyclotriphosphazenes containing different spiro-rings with different unsymmetrical pendant arms.…”

SINGLY, DOUBLY AND TRIPLY BRIDGED POLYAZAHETEROPHANES DERIVED FROM HEXACHLOROCYCLOTRIPHOSPHAZENE, N3P3Cl6

“…Such a mechanical interpretation of chemical shift variations as a function of bond angles is quite similar to the one we proposed recently within the series of MONOSPIRO, DISPIRO and TRISPIRO cyclotriphosphazenes. '0* 16 It may be predicted, from the "springs and rings" mechanical model we mentioned above, that the distance between rings, i.e., the effective volume of the cage (or "barrel") for recognition of host molecules, is smaller in folded conformers than in the non-folded ones. Thus, the latter will complex smaller host molecules than the former.…”