An animal model of the procognitive properties of cysteine protease inhibitor and immunomodulatory peptides based on colostrum.

Stańczykiewicz, Bartłomiej; Jakubik-Witkowska, Marta; Polanowski, Antoni; Trziszka, Tadeusz; Rymaszewska, Joanna

doi:10.17219/acem/62536

Cited by 7 publications

(7 citation statements)

References 17 publications

(28 reference statements)

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“…Previous research conducted with the use of ovocystatin in animal models revealed that its oral intake correlated with improved cognitive functions assessed with the Morris water maze. Interestingly, these effects were also observed in young rats [ 112 ]. Similar results were obtained in the animal model of B6C3-Tg transgenic mice used for the recreation of Alzheimer’s disease pathology.…”

Section: Cystatin Cmentioning

confidence: 88%

Cystatins: unravelling the biological implications for neuroprotection

Stańczykiewicz,

Łuc,

Banach

et al. 2023

Arch Med Sci

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Cystatins, a family of proteins known for their inhibitory role against cysteine proteases, have garnered significant attention in the field of neurodegeneration. Numerous genetic, experimental and clinical studies concerning cystatin C suggest it plays an important role in the course of neurodegenerative diseases. Its beneficial effects are associated with cysteine protease inhibition, impact on β-amyloid aggregation as well as regulation of cell proliferation, autophagy and apoptosis. Cystatin isolated from chicken egg white, called Ovocystatin, has been widely used in medical and pharmaceutical research due to its structural and biological similarities to human cystatin C. This article focuses on the potential use of cystatins, with special emphasis on easily-obtained Ovocystatin, in the treatment of neurodegenerative diseases, such as dementia. The current evidence on cystatin use has been portrayed shedding light on their mechanisms of action and therapeutic implications for neuroprotection and maintenance of cognitive functions.

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Section: Cystatin Cmentioning

confidence: 88%

Cystatins: unravelling the biological implications for neuroprotection

Stańczykiewicz,

Łuc,

Banach

et al. 2023

Arch Med Sci

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“…It has been shown up until now, that ovocystatin has a beneficial impact on cognitive function in young rats, and might prevent aging-related cognitive impairment in older animals [ 21 ] and reduce memory decline in APP/PS1 mice model [ 23 , 24 ]. However, its potential molecular mechanism of action is not explained and needs to be examined in detail.…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, bioactive peptides/proteins are promising candidates for use as the inhibitors of Aβ fibril formation, such as ovocystatin (ovoC). Interestingly, ovocystatin improves cognitive function in young rats [ 21 ] and prevents aging-related cognitive impairment in older animals [ 22 ]. Moreover, recently published studies showed that the administration of ovoC in drinking water might be effective in the prevention of cognitive deterioration in APP/PS1 mice [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Ovocystatin on Amyloid β 1-42 Aggregation—In Vitro Studies

Stańczykiewicz

Goszczyński

Migdał

et al. 2023

IJMS

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Amyloid β peptides (Aβ) aggregating in the brain have a potential neurotoxic effect and are believed to be a major cause of Alzheimer’s disease (AD) development. Thus, inhibiting amyloid polypeptide aggregation seems to be a promising approach to the therapy and prevention of this neurodegenerative disease. The research presented here is directed at the determination of the inhibitory activity of ovocystatin, the cysteine protease inhibitor isolated from egg white, on Aβ42 fibril genesis in vitro. Thioflavin-T (ThT) assays, which determine the degree of aggregation of amyloid peptides based on fluorescence measurement, circular dichroism spectroscopy (CD), and transmission electron microscopy (TEM) have been used to assess the inhibition of amyloid fibril formation by ovocystatin. Amyloid beta 42 oligomer toxicity was measured using the MTT test. The results have shown that ovocystatin possesses Aβ42 anti-aggregation activity and inhibits Aβ42 oligomer toxicity in PC12 cells. The results of this work may help in the development of potential substances able to prevent or delay the process of beta-amyloid aggregation—one of the main reasons for Alzheimer’s disease.

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“…4 BC or its formulations have pleiotropic properties that could be useful in individuals with a decline in cognitive functions, which include antioxidant, anti-inflammatory, cellular survival, and inhibition of Aβ-fibril aggregation. [5][6][7][8][9][10] Several studies have shown that reactive oxygen species, neuroinflammation, and senescent cells are involved in the pathogenesis of impairment of cognitive function. 11 Colostrum was investigated in a small number of clinical studies, and the authors reported the beneficial effect of using colostrum in mild-moderate impairment of cognitive functions in Alzheimer's disease.…”

Section: Introductionmentioning

confidence: 99%

The Reasons Behind the Salubrious of Colostrum on the Cognitive Functions: A Systematic Review

2022

TJNPR

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Bovine colostrum (BC) is rich in many vitamins, minerals, and antioxidant substances. Its supplementation provides health benefits, particularly for athletes. This systematic review was carried out to update on the benefit of BC or its formulations (e.g., colostrinin) on the cognitive functions or their related biomarkers in experimental and human studies. Full texts or abstracts of 219 articles as reports of narrative or systematic reviews, randomized controlled clinical trials, observational studies, and experimental studies (in vitro, ex vivo, and in vivo) were included after searches in PubMed, Europe PMC, Google scholar databases. The full texts of eligible articles (25 articles) were assessed and their results were summarized in different categories according to the study design. Bovine colostrum or its related formulations have been shown to be useful as they improve cognitive functions and their biomarkers. Compatible results were observed in experimental and human studies. Further studies are mandatory to elucidate the rationale for using (BC) in healthy subjects and patients with impaired of cognitive functions.

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An animal model of the procognitive properties of cysteine protease inhibitor and immunomodulatory peptides based on colostrum.

Cited by 7 publications

References 17 publications

Cystatins: unravelling the biological implications for neuroprotection

Cystatins: unravelling the biological implications for neuroprotection

Effect of Ovocystatin on Amyloid β 1-42 Aggregation—In Vitro Studies

The Reasons Behind the Salubrious of Colostrum on the Cognitive Functions: A Systematic Review

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