An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis

Uluocak, Nıhat; Atılgan, Doğan; Erdemır, Fikret; Parlaktaş, Bekir Süha; Yaşar, Adem; Erkorkmaz, Ünal; Akbaş, Ali

doi:10.1007/s11255-010-9706-y

Cited by 17 publications

(23 citation statements)

References 33 publications

(36 reference statements)

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“…Due to the difficulty in exploring these mechanisms in patients, the use of animal models of priapism has become of utmost importance to decipher this devastating clinical challenge [19]. Animal models for priapism include dogs [20, 21], rabbits [22], rats [23–27], and mice [28–41]. …”

Section: Priapismmentioning

confidence: 99%

Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia

Claudino

Fertrin

2012

Anemia

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Sickle cell anemia is one of the best studied inherited diseases, and despite being caused by a single point mutation in theHBBgene, multiple pleiotropic effects of the abnormal hemoglobin S production range from vaso-occlusive crisis, stroke, and pulmonary hypertension to osteonecrosis and leg ulcers. Urogenital function is not spared, and although priapism is most frequently remembered, other related clinical manifestations have been described, such as nocturia, enuresis, increased frequence of lower urinary tract infections, urinary incontinence, hypogonadism, and testicular infarction. Studies on sickle cell vaso-occlusion and priapism using bothin vitroandin vivomodels have shed light on the pathogenesis of some of these events. The authors review what is known about the deleterious effects of sickling on the genitourinary tract and how the role of cyclic nucleotides signaling and protein kinases may help understand the pathophysiology underlying these manifestations and develop novel therapies in the setting of urogenital disorders in sickle cell disease.

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Section: Priapismmentioning

confidence: 99%

Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia

Claudino

Fertrin

2012

Anemia

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“…However, whether adenosine is a potential agent which mediates both stroke and priapism needs to be further discussed. Recent studies showed that in corpus cavernosum ischaemia-reperfusion mouse, many oxidative injury parameters like superoxide dismutase (SOD), catalase, malondialdehyde (MDA) and NO in the tissues were all upregulated, and melatonin, which also played neuroprotective actions in stroke,35 could attenuate the activity of SOD and the levels of MDA and NO 36. These conclusions strongly suggested that melatonin may be involved in the stroke-induced priapism pathway.…”

Section: Discussionmentioning

confidence: 99%

Effect of ischaemic brain injury on sexual function in adult mice

et al. 2016

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ObjectivePriapism refers to a condition with persistent abnormal erection of the penis, which is usually caused by disease or injury in the brain or spinal cord, or obstruction to the outflow of blood through the dorsal vein at the root of the penis, without sexual desires. The effect of cerebral ischaemia on sexual function is unknown. The aim of this study is to explore whether priapism occurs in adult mice. Furthermore, we examined the relationship between priapism and the region of infarct in the brain.DesignAdult male CD-1 mice who underwent permanent middle cerebral artery occlusion (pMCAO) were closely examined from 2 hours to 14 days postoperation.ResultsWe found that priapism occurs in ∼80% of the mice with pMCAO, which could persist up to 14 days. Further study has demonstrated that the occurrence of priapism is related to the infarct region: priapism is found only in mice with ischaemic injury extending to the hypothalamus and the hippocampus regions.ConclusionOur result suggested priapism may be used as a deep brain injury marker for evaluating brain injury in mice after pMCAO.

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“…[30], Uluocak et al. [31] and Sanli et al. [32] devised a similar vacuum induced priapism rat model to investigate the medication in preventing priapism induced detrimental effects on erectile tissue.…”

Section: In Vivo Animal Modelsmentioning

confidence: 99%

“…Evliyaoglu et al [28,29], Jin et al [30], Uluocak et al [31] and Sanli et al [32] devised a similar vacuum induced priapism rat model to investigate the medication in preventing priapism induced detrimental effects on erectile tissue. The vacuum erectile device (VED) is a cone-tipped standard 50 cc irrigation syringe for Foley urethral catheters [28][29][30]32].…”

Section: Model Established By Vacuum + Constrictor Bandmentioning

confidence: 99%

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In Vitro and in Vivo Animal Models in Priapism Research

Dong

Deng

Wang

et al. 2011

The Journal of Sexual Medicine

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Introduction Priapism is an enigmatic yet devastating clinical phenomenon. In the last two decades, the use of various animal models to study this disorder has dramatically advanced our understanding of this mysterious disorder. Aim This report reviews various animal models used to study ischemic priapism and informs basic science researchers the broad view of priapism research. Methods Retrospective review of pertinent literature from the last two decades via PubMed search using the keywords “ischemic priapism” and “priapism model.” Main Outcome Measures Findings on the animal models used in ischemic priapism research and its advantages and limitations. Results In vitro and in vivo animal models varying from dogs, cats, rabbits, rats to mice were used in priapism research. In vitro models included: (i) corpora cavernosa smooth muscle (CCSM) strip in organ bath; (ii) corporal tissue binding assay; (iii) CCSM cell culture under hypoxia/anoxia. In vivo models could be categorized as: (i) pharmacologically induced by corpus cavernosum medicine injection; (ii) ventilation induced by tidal volume control; (iii) mechanical induced by a constrictor band placed around the base of the penis combined with induced erection; (iv) genetic engineered by intracorporal gene transfer, transgenic, or gene knock-out. Conclusions The ischemic priapism animal models are shifting from pharmaceutically or mechanically induced to genetically engineered. The knowledge generated by those models is enhancing our understanding and management of this clinical challenge.

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An animal model of ischemic priapism and the effects of melatonin on antioxidant enzymes and oxidative injury parameters in rat penis

Cited by 17 publications

References 33 publications

Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia

Sickling Cells, Cyclic Nucleotides, and Protein Kinases: The Pathophysiology of Urogenital Disorders in Sickle Cell Anemia

Effect of ischaemic brain injury on sexual function in adult mice

In Vitro and in Vivo Animal Models in Priapism Research

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