An aniline trimer-based multifunctional sensor for colorimetric Fe3+, Cu2+ and Ag+ detection, and its complex for fluorescent sensing of L-tryptophan

Pundi, Arul; Chang, Chi‐Jung; Chen, Yi-Shao; Chen, Jem-Kun; Yeh, Jui‐Ming; Zhuang, Cai-Shan; Lee, Ming-Ching

doi:10.1016/j.saa.2020.119075

Cited by 29 publications

(7 citation statements)

References 51 publications

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“…Previous studies also proved that the thiourea group had a binding effect on certain amino acids, including L-tryptophan. [24] The quantitative tissue adhesion strength of HA-NCSN/Ag + hydrogels was further evaluated through a lap shear tensile test as shown in Figure 4c. The adhesion strength of 0.12%, 0.15%, and 0.17% group was 2.85, 2.11, and 1.66 kPa, respectively (Figure 4d,e), showing a decreased tendency with the increase of Ag + concentration.…”

Section: Characterization Of Ha-ncsn/ag + Hydrogelmentioning

confidence: 99%

“…[23] For instance, Arul Pundi et al discovered that sensors incorporating aniline components and chiral thiourea binding sites could effectively detect Fe 3+ , Cu 2+ , Ag + ions, and L-tryptophan. [24] While Daisuke Nagai et al synthesized a thiourea grated polyallylamine hydrogel for Hg 2+ absorption. [25] However, there is no report about thiourea based positive ion chelating hydrogels for the application in regenerative medicine.…”

Section: Introductionmentioning

confidence: 99%

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Thiourea‐Cation Chelation Based Hydrogel and its Application as Antibacterial Dressing for the Repair of Diabetic Wound

Meng,

Lin,

Cheng

et al. 2024

Adv Funct Materials

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For various chronic wounds, bacterial infection is one of the important reasons that hinder their healing. Ion‐crosslinked antibacterial hydrogel dressings based on Ag+, Cu2+ and Zn2+, have made progress in clinical application. However, the toxicity of released metal ions cannot be ignored. Therefore, how to ensure the antibacterial performance of hydrogel dressing while reducing the amount of metal ions is a major challenge for the fabrication of metal ion based antibacterial hydrogel. In this study, a general method is proposed to design cationic ion‐crosslinked hydrogel based on thiourea groups. Taking the hydrogel formed by mixing thiourea modified hyaluronic acid (H‐ANCSN) with Ag+ (HA‐NCSN/Ag+ hydrogel) as an example, the characteristics and application potential of this kind of hydrogel are thoroughly explored. Due to the strong cationic chelation characteristics of thiourea groups, HA‐NCSN/Ag+ hydrogel can gel at low Ag+ concentration and achieve long‐term slow release of Ag+ at stable concentration to balance the antibacterial and biocompatible properties. Moreover, this dynamic thiourea‐Ag+ crosslinking also endowed the hydrogel with the property of “gelation and encapsulation first, injection to cover wound when necessary”. Then, the mangiferin self‐assembled nanoparticles are loaded into HA‐NCSN/Ag+ hydrogel as the radical oxygen species scavenger.

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Section: Characterization Of Ha-ncsn/ag + Hydrogelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Thiourea‐Cation Chelation Based Hydrogel and its Application as Antibacterial Dressing for the Repair of Diabetic Wound

Meng,

Lin,

Cheng

et al. 2024

Adv Funct Materials

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“…Therefore, there is a high interest in the detection of this important amino acid in biological fluids, including blood, urine, and saliva, in medical studies, in particular in the area of neuroscience and oncology [ 11 , 12 , 13 ]. A variety of analytical methods have been reported for the determination of L-tryptophan, which include for instance high-performance liquid chromatography (HPLC) [ 14 , 15 , 16 ] and colorimetric and spectrofluorometric methods [ 17 , 18 , 19 , 20 ]. These methods require expensive equipment and trained personnel and are time-consuming.…”

Section: Introductionmentioning

confidence: 99%

Highly Sensitive and Selective Detection of L-Tryptophan by ECL Using Boron-Doped Diamond Electrodes

Scorsone,

Stewart,

Hamel

2024

Sensors

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L-tryptophan is an amino acid that is essential to the metabolism of humans. Therefore, there is a high interest for its detection in biological fluids including blood, urine, and saliva for medical studies, but also in food products. Towards this goal, we report on a new electrochemiluminescence (ECL) method for L-tryptophan detection involving the in situ production of hydrogen peroxide at the surface of boron-doped diamond (BDD) electrodes. We demonstrate that the ECL response efficiency is directly related to H2O2 production at the electrode surface and propose a mechanism for the ECL emission of L-tryptophan. After optimizing the analytical conditions, we show that the ECL response to L-tryptophan is directly linear with concentration in the range of 0.005 to 1 µM. We achieved a limit of detection of 0.4 nM and limit of quantification of 1.4 nM in phosphate buffer saline (PBS, pH 7.4). Good selectivity against other indolic compounds (serotonin, 3-methylindole, tryptamine, indole) potentially found in biological fluids was observed, thus making this approach highly promising for quantifying L-tryptophan in a broad range of aqueous matrices of interest.

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“…[10,[12][13][14][15][16][17][18][19] For those reasons, it is needed to develop colorimetry sensors to simply detect metals or amino acids. [20][21][22][23] Copper is essential for physiological body functions like mitochondrial electron transfer, neurotransmission process, melanin production, and bone formation. However, lack or excess of cupric ions causes severe impairments, for example, Menkes's, Wilson's, prion diseases, and renal problems.…”

Section: Introductionmentioning

confidence: 99%

A New Chromone‐based Sequential Functioning Colorimetric Chemosensor for Cu²⁺ and Cysteine in Near‐perfect Aqueous Media

2023

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A selective chromone‐containing colorimetric chemosensor DOCC ((E)‐N,N‐dimethyl‐2‐((4‐oxo‐4H‐chromen‐3‐yl)methylene)hydr azine‐1‐carbothioamide) was designed for the sequential probing of Cu2+ and cysteine. DOCC exhibited a marked color variation from colorless to pale yellow and had the lowest limit of detection (0.30 μM) among the chromone‐based colorimetric sensors for Cu2+ in near‐perfect aqueous media. DOCC could work to probe and quantify Cu2+ in real water samples with great recovery (98‐102%). DOCC could discriminate Cu2+ using the test kit down to 10 μM. On the other hand, Cu2+‐2⋅DOCC could selectively detect cysteine (Cys) in a sequential step through the demetallation reaction. Cu2+‐2⋅DOCC showed that its color returned from pale yellow to colorless only in the presence of Cys and its limit of detection was calculated to be 6.62 μM. The practical applications for Cys were successfully achieved in water samples with perfect recovery (99–100%) and pH tests at 7–9. FT‐IR, Job plot, ESI‐MS, and DFT calculations were applied to explain the sensing mechanisms of Cu2+ by DOCC and Cys by Cu2+‐2⋅DOCC.

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An aniline trimer-based multifunctional sensor for colorimetric Fe3+, Cu2+ and Ag+ detection, and its complex for fluorescent sensing of L-tryptophan

Cited by 29 publications

References 51 publications

Thiourea‐Cation Chelation Based Hydrogel and its Application as Antibacterial Dressing for the Repair of Diabetic Wound

Thiourea‐Cation Chelation Based Hydrogel and its Application as Antibacterial Dressing for the Repair of Diabetic Wound

Highly Sensitive and Selective Detection of L-Tryptophan by ECL Using Boron-Doped Diamond Electrodes

A New Chromone‐based Sequential Functioning Colorimetric Chemosensor for Cu²⁺ and Cysteine in Near‐perfect Aqueous Media

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An aniline trimer-based multifunctional sensor for colorimetric Fe3+, Cu2+ and Ag+ detection, and its complex for fluorescent sensing of L-tryptophan

Cited by 29 publications

References 51 publications

Thiourea‐Cation Chelation Based Hydrogel and its Application as Antibacterial Dressing for the Repair of Diabetic Wound

Thiourea‐Cation Chelation Based Hydrogel and its Application as Antibacterial Dressing for the Repair of Diabetic Wound

Highly Sensitive and Selective Detection of L-Tryptophan by ECL Using Boron-Doped Diamond Electrodes

A New Chromone‐based Sequential Functioning Colorimetric Chemosensor for Cu2+ and Cysteine in Near‐perfect Aqueous Media

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Product

Resources

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A New Chromone‐based Sequential Functioning Colorimetric Chemosensor for Cu²⁺ and Cysteine in Near‐perfect Aqueous Media