An Angiotensin Converting Enzyme Inhibitor, Benazepril Can Be Transformed to an Active Metabolite, Benazeprilat, by the Liver of Dogs with Ascitic Pulmonary Heartworm Disease
Abstract:ABSTRACT. To examine whether an angiotensin converting enzyme (ACE) inhibitor, benazepril, can be transformed to the active metabolite, benazeprilat, by severely injured liver of dogs with ascitic heartworm disease, benazepril hydrochloride was administered orally to dogs once daily for 7 consecutive days at a dose rate of 0.29 mg/kg to 0.63 mg/kg of body weight, and plasma benazepril and benazeprilat concentrations were determined on the 1st and 7th administration days. In 7 dogs with ascitic pulmonary heartw… Show more
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