An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR-204 promotes the invasion and metastasis of triple-negative breast cancer

Yang, Fang; Shen, Yan; Zhang, Wenwen; Jin, Juan; Huang, Doudou; Fang, Hehui; Ji, Wenfei; Shi, Ying; Tang, Lin; Chen, Weiwei; Zhou, Guohua; Guan, Xiaoxiang

doi:10.1038/s41418-018-0123-6

Cited by 101 publications

(87 citation statements)

References 42 publications

(47 reference statements)

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“…Immunohistochemistry. Immunohistochemical staining was performed as previously described (24). Staining was scored as: i) ++++ if >80% tumor cells were immuno-positive; ii) +++ for 51-80%; iii) ++ for 11-50%; iv) + for 1-10% cells; and v) -if <1% of the tumor cells were positively stained.…”

Section: Methodsmentioning

confidence: 99%

BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer

Wang

et al. 2020

Oncol Lett

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Triple-negative breast cancer (TNBC) is associated with poor clinical prognosis due to a lack of effective therapeutic options. The expression of B-cell lymphoma/leukemia 11A (BCL11A) has been indicated to correlate with TNBC carcinogenesis, though the precise mechanisms of BCL11A-induced tumorigenesis in TNBC remain unclear. Using data retrieved from The Cancer Genome Atlas (TCGA) database, the present study demonstrated that BCL11A expression was upregulated in TNBC, compared with other types of breast cancer. Furthermore, in a tissue microarray of 140 patients with breast cancer, an elevated BCL11A level was correlated with unfavorable overall survival (OS), and exogenous BCL11A-knockdown was subsequently verified to inhibit tumor growth and metastasis in TNBC. Notably, the same tissue microarray revealed that a favorable patient outcome was associated with high expression levels of BCL11A and androgen receptor (AR). Moreover, BCL11A-knockdown significantly inhibited the expression level of AR and further had an influence on proliferation, migration and invasion in TNBC cell lines. Collectively, the results of the current study indicate the function of BCL11A in TNBC progression, and provide new insights into the unique mechanism of BCL11A in AR regulation, emphasizing the significance of more research on BCL11A and AR regulation in TNBC molecular treatment.

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Section: Methodsmentioning

confidence: 99%

BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer

Wang

et al. 2020

Oncol Lett

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“…Being down‐regulated, miR‐129‐5p is associated with high cell proliferation, migration, and invasionAR negatively induced lncRNA (ARNILA) up‐regulation was related to poor survival in TNBC patients and promoted EMT, invasion and metastasis by sponging miR‐204. One target of ARNILA is SOX4 which is known to induce EMT and contribute to BC progression . GAS5, which is down‐regulated, can suppress TNBC progression by competitively binding miR‐196a‐5p which is targeted to FOXO1/PI3K/AKT signal pathway …”

Section: Lncrnas and The Triple‐negative Subtypementioning

confidence: 99%

Long non‐coding RNAs differential expression in breast cancer subtypes: What do we know?

et al. 2019

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Breast Cancer (BC) is the most commonly diagnosed cancer and is the leading cause of cancer deaths in women. BC is a heterogeneous disease with different clinical and genetic features. According to immunohistochemical markers, BC is subdivided into four main subtypes: luminal A, luminal B, ERBB2 positive and triple negative. Long non‐coding RNAs (lncRNAs) are transcripts with more than 200 nucleotides and deregulated lncRNAs are associated with human diseases, including BC. In order to improve BC molecular classification, non‐coding RNAs (ncRNAs), including lncRNAs, have been used. In this review, we focus on lncRNAs with differential expression in BC subtypes and how these RNAs may act to contribute to BC heterogeneity. We also emphasize the potential of these lncRNAs as biomarkers.

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“…Long noncoding RNA (lncRNAs) and circular RNAs (cir-cRNAs) are important factors in human cancer pathogenesis [15,20,21]. Both lncRNAs and circRNAs lack the ability to encode proteins and circRNAs are characterized by the covalent conjunction and lacking of the 3′ and 5′ end.…”

Section: Discussionmentioning

confidence: 99%

A novel circular RNA circENTPD7 contributes to glioblastoma progression by targeting ROS1

et al. 2020

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Background: Circular RNAs (circRNAs) are identified to play an important role in many human cancers, such as glioblastoma. However, the potential mechanisms underlying the relationship between circRNAs and glioblastoma pathogenesis are still elusive. This study is designed to investigate the role of circRNAs in glioblastoma progression. Methods:The present study is designed to investigate the mechanism by which circRNAs involves in glioblastoma pathogenesis. By using circRNAs microarray, we detected the dysregulated circRNAs and identified an up-regulated circRNA, circENTPD7 in glioblastoma tissues. Cell proliferation was measured using a CCK-8 assay. Cell clone formation ability was assessed with a clone formation test. We used the bioinformatics website to predict circRNA-miRNA and miRNA-mRNA interactions. CircRNA-miRNA interaction was confirmed by dual-luciferase reporter assays and RNA-RNA pulldown assay.Results: circENTPD7 (hsa_circ_0019421) was upregulated in glioblastoma tissues. Kaplan-Meier survival analysis indicated that glioblastoma patients had a poor overall survival when circENTPD7 expression levels were high. Knockdown of circENTPD7 inhibited the motility and proliferation of glioblastoma cells. Moreover, we demonstrated that circENTPD7 acted as a sponge of miR-101-3p to regulate the expression of ROS1 further promoted the proliferation and motility of glioblastoma cells. Conclusions:Taken together, these findings indicate that circRNA circENTPD7 promotes glioblastoma cell proliferation and motility by regulating miR-101-3p/ROS1.

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An androgen receptor negatively induced long non-coding RNA ARNILA binding to miR-204 promotes the invasion and metastasis of triple-negative breast cancer

Cited by 101 publications

References 42 publications

BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer

BCL11A confers cell invasion and migration in androgen receptor‑positive triple‑negative breast cancer

Long non‐coding RNAs differential expression in breast cancer subtypes: What do we know?

A novel circular RNA circENTPD7 contributes to glioblastoma progression by targeting ROS1

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