An ancient transcription activator is required for the multiciliogenesis program
Haochen Jiang,
Mengting Hua,
Mei Ding
et al.
Abstract:Multiciliogenesis is an evolutionarily conserved process required a unique transcriptional program. The mechanisms governing multiciliogenesis are incompletely understood. Here we show that an ancient transcription activator, Edf1, is essential for the multiciliogenesis program. Mice lacking Edf1 exhibit postnatal hydrocephalus and delayed multiciliated cells (MCCs) differentiation. Functional studies reveal that MCCs in Edf1-/-mice have defects in tissue-level polarity and reduced motility. These defects resu… Show more
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