An Anatomical Study of Converging Sensory Pathways Within the Cerebral Cortex of the Monkey

Jones, Edward G.; Powell, T. P. S.

doi:10.1093/brain/93.4.793

Cited by 1,612 publications

(684 citation statements)

References 0 publications

Supporting

Mentioning

640

Contrasting

Unclassified

Order By: Relevance

“…Thus, it is tempting to conclude that highly complex pyramidal cells in the dorsolateral gPFC is a characteristic of the latter species, which may differ from that in other primates that diverged earlier, such as New World monkeys and the great apes. Alternatively, the apparent species differences may reflect regional variation in neuronal maturation rates (Jacobs and Scheibel, 1993; Jacobs et al, 1995, 1997; Page et al, 2002; Duan et al, 2003; Elston et al, 2009, 2010a,b) or arise through sampling different subsets of projection neurons in the different cortical areas, which have been shown to differ in both their morphology (Schofield et al, 1987; Hallman et al, 1988; Hübener and Bolz, 1988; de Lima et al, 1990; Hübener et al, 1990; Einstein, 1996; Matsubara et al, 1996; Duan et al, 2002; Soloway et al, 2002; Elston and Rosa, 2006) and density (Jones and Powell, 1970; Barbas, 1992; Young, 1992; Pandya and Yeterian, 2000; Petrides, 2000; Collins et al, 2005) in different cortical areas. In either case, the result is consistent with our main conclusion that pyramidal cells develop differently among cortical areas and mature into specialized circuits.…”

Section: Discussionmentioning

confidence: 99%

Pyramidal cells in prefrontal cortex of primates: marked differences in neuronal structure among species

Elston¹,

Benavides-Piccione

Elston³

et al. 2011

Front. Neuroanat.

104

105

View full text Add to dashboard Cite

The most ubiquitous neuron in the cerebral cortex, the pyramidal cell, is characterized by markedly different dendritic structure among different cortical areas. The complex pyramidal cell phenotype in granular prefrontal cortex (gPFC) of higher primates endows specific biophysical properties and patterns of connectivity, which differ from those in other cortical regions. However, within the gPFC, data have been sampled from only a select few cortical areas. The gPFC of species such as human and macaque monkey includes more than 10 cortical areas. It remains unknown as to what degree pyramidal cell structure may vary among these cortical areas. Here we undertook a survey of pyramidal cells in the dorsolateral, medial, and orbital gPFC of cercopithecid primates. We found marked heterogeneity in pyramidal cell structure within and between these regions. Moreover, trends for gradients in neuronal complexity varied among species. As the structure of neurons determines their computational abilities, memory storage capacity and connectivity, we propose that these specializations in the pyramidal cell phenotype are an important determinant of species-specific executive cortical functions in primates.

show abstract

Section: Discussionmentioning

confidence: 99%

Pyramidal cells in prefrontal cortex of primates: marked differences in neuronal structure among species

Elston¹,

Benavides-Piccione

Elston³

et al. 2011

Front. Neuroanat.

104

105

View full text Add to dashboard Cite

show abstract

“…Input from the premotor (area 6) cortex reaches both banks of the caudal two-thirds of the principalis and is also preferentially directed to the mid-ventral principalis region, to the same site which receives the somatosensory input. The premotor cortex, with its known reciprocal connections with the motor cortex, 28 -69 may provide a link underlying the execution phase of tasks supported by the principalis cortex. Indeed a distinct class of neurons in the caudalhalf of the principalis fires in association with the motor aspect of a task.…”

Section: Discussionmentioning

confidence: 99%

Cortical afferent input to the principals region of the rhesus monkey

1985

View full text Add to dashboard Cite

Abstract-The sources of ipsilateral cortical afferent projections to regions along both banks of the principalis sulcus in the prefrontal cortex were studied with horseradish peroxidase in macaque monkeys. The principalis cortex receives a substantial proportion of its projections from neighboring prefrontal regions. However, differences were noted in the distribution of labeled cells projecting to the various principalis regions. These differences were most marked with respect to the relative proportion of cells originating in visual, auditory, somatosensory, premotor and limbic cortical areas. The findings indicate that the caudal ventral principalis region receives projections from both visual and visuomotor regions, whereas the anterior tip of the principalis appears to be the major target of projections from auditory association regions. The ventral bank at the middle extent of the principalis was the only case with a significant proportion of labeled cells in somatosensory association and premotor regions. There was a consistent increase in the proportion of labeled cells in limbic cortical areas projecting to more rostral principalis sites, irrespective of whether the injection was placed in the dorsal or ventral bank.These findings suggest that the caudal principalis region has a visual-visuomotor and the rostral, an auditorylimbic bias with respect to the long projections they receive.

show abstract

“…In support of this view was the absence of strong anatomical links between the areas of different modalities at the level of the first stages of sensory processing (see Jones and Powell, 1970). Recent anatomical and electrophysiological studies in non-human primates as well as human functional brain studies led to a reappraisal of this concept (see Ghazanfar and Schroeder, 2006;Driver and Noesselt, 2008 for recent reviews) and highlight that the mechanisms for multisensory interplay are believed to include several levels of brain processing, from the thalamus to the primary sensory areas and higher stages of sensory processing.…”

Section: Introductionmentioning

confidence: 96%

Multisensory anatomical pathways

2009

View full text Add to dashboard Cite

In order to interact with the multisensory world that surrounds us, we must integrate various sources of sensory information (vision, hearing, touch. . .). A fundamental question is thus how the brain integrates the separate elements of an object defined by several sensory components to form a unified percept. The superior colliculus was the main model for studying multisensory integration. At the cortical level, until recently, multisensory integration appeared to be a characteristic attributed to high-level association regions. First, we describe recently observed direct cortico-cortical connections between different sensory cortical areas in the non-human primate and discuss the potential role of these connections. Then, we show that the projections between different sensory and motor cortical areas and the thalamus enabled us to highlight the existence of thalamic nuclei that, by their connections, may represent an alternative pathway for information transfer between different sensory and/or motor cortical areas. The thalamus is in position to allow a faster transfer and even an integration of information across modalities. Finally, we discuss the role of these non-specific connections regarding behavioral evidence in the monkey and recent electrophysiological evidence in the primary cortical sensory areas.

show abstract

An Anatomical Study of Converging Sensory Pathways Within the Cerebral Cortex of the Monkey

Cited by 1,612 publications

References 0 publications

Pyramidal cells in prefrontal cortex of primates: marked differences in neuronal structure among species

Pyramidal cells in prefrontal cortex of primates: marked differences in neuronal structure among species

Cortical afferent input to the principals region of the rhesus monkey

Multisensory anatomical pathways

Contact Info

Product

Resources

About