An Analytical Study and Anti-Inflammatory and Analgesic Effects ofHarpagophytum procumbensandHarpagophytum zeyheri

Abstract

The iridoids of Harpagophytum procumbens and Harpagophytum zeyheri were studied by CLHP. Harpagoside is the main iridoid for both drugs whereas 8-p-coumaroylharpagide is a representative iridoid of Harpagophytum zeyheri only. The ratio harpagoside/8-p-coumaroylharpagide can be used to distinguish chemically both species. For commercial dried aqueous extracts this ratio is intermediate because they are probably prepared from a mixture of H. procumbens and H. zeyheri drugs. The aqueous extracts of both drugs show similar analgesic and anti-inflammatory properties. Harpagophytum procumbens and Harpagophytum zeyheri should be accepted as sources for the drug Harpagophyti radix.

Phytochemical profile and analgesic evaluation of Vitex cymosa leaf extracts

“…It is interesting to note that Vitex cymosa is used in the Brazilian traditional medicine to treat rheumatoid arthritis. Also noteworthy, is the fact that one of the most prescribed phytomedicines to treat degenerative diseases of the musculoskeletal system nowadays is the South African plant Harpagophytum procumbens D.C., known as Devil's Claw, which active principles are claimed to be iridoid glucosides (Stewart & Cole, 2005;Baghdikian et al, 1997).…”

De Novo Regeneration of Scrophularia yoshimurae YAMAZAKI (Scrophulariaceae) and Quantitative Analysis of Harpagoside, an Iridoid Glucoside, Formed in Aerial and Underground Parts of In Vitro Propagated and Wild Plants by HPLC.

“…Since harpagoside and other iridoid glucosides of Scrophularia spp. have shown anti-inflammatory, 30,31) antihepatotoxic and immunostimulant 32) properties, in vitro propagated plants of S. yoshimurae, which contain fairly high amount of harpagoside, could be used for pharmacological studies. These findings may also be useful in rapid micropropagation, commercial cultivation and germplasm conservation of S. yoshimurae.…”

Production of gastro-resistant coated tablets prepared from the hydroethanolic standardized roots extract of Harpagophytum procumbens DC.

“…This perennial herbaceous plant, popularly known as "devil's claw", grows naturally in the Kalahari desert and in the steppe region of Namibia in southwestern Africa. Its secondary tubular roots, commonly associated with the term "devil's claw" by its shape, have been widely used in traditional medicine with several therapeutic indications, especially as antiinflammatory and analgesic (Baghdikian et al, 1997).…”

“…This perennial herbaceous plant, popularly known as "devil's claw", grows naturally in the Kalahari desert and in the steppe region of Namibia in southwestern Africa. Its secondary tubular roots, commonly associated with the term "devil's claw" by its shape, have been widely used in traditional medicine with several therapeutic indications, especially as antiinflammatory and analgesic (Baghdikian et al, 1997 exclusive use of vegetal active raw materials whose safety and effectiveness are based on data of safe and effective use published in the technical-scientific literature, and which are designed to be used without supervision by a physician for diagnostic, prescription or monitoring purposes". Thus, in Brazil, the dry extract produced from the roots of the H. procumbens DC.…”