An Analytic Method to Determine the Optimal Time for the Induction Phase of Anesthesia
Mohamed A. Zaitri,
Cristiana J. Silva,
Delfim F. M. Torres
Abstract:We obtain an analytical solution for the time-optimal control problem in the induction phase of anesthesia. Our solution is shown to align numerically with the results obtained from the conventional shooting method. The induction phase of anesthesia relies on a pharmacokinetic/pharmacodynamic (PK/PD) model proposed by Bailey and Haddad in 2005 to regulate the infusion of propofol. In order to evaluate our approach and compare it with existing results in the literature, we examine a minimum-time problem for ane… Show more
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