It is well known that asymmetric vane spacing can result in decreased levels of the excitation at specific frequencies. In this paper, the resonant response reduction of compressor blades due to asymmetric vane spacing is studied both theoretically and experimentally for the most probable asymmetric vane in which the vane count of the upper and lower half is slightly different. First, a method for predicting the vibratory stress of the blade for the asymmetric spacing vane is proposed. Secondly, using a simple model of the asymmetric vane, a parametric study is carried out to clarify the influence of blade damping and vane count on the blade resonant response reduction. Finally, experiments are carried out to verify the validity of the proposed method and the effect of asymmetric vane spacing on resonant stress response using a 3 stage scaled-model compressor.