“…Often, specific diagnosis is not possible with cytology, and it is not successful in the differential diagnosis between typical and atypical proliferative lesions and between invasive or in situ carcinomas. Surgical biopsy, which represents the gold standard, with preoperative localization of the lesion has many relevant problems related to the choice of anesthesia (local or general), the type of preoperative localization, the possibility of dislocation of the repere, the excision of a large sample of tissue, and accuracy (missed lesion, 5-17%) [17]. Thus an x-ray of the specimen is usually requested.…”