An analysis of the relationship between microneedle spacing, needle force and skin strain during the indentation phase prior to skin penetration

Potts, Matthew R.; Evans, Samuel Lewin; Pullin, Rhys; Coulman, Sion; Birchall, James Caradoc; Wyatt, Hayley

doi:10.1080/10255842.2022.2136486

Cited by 3 publications

(1 citation statement)

References 19 publications

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“…It is important to note that smaller tip diameters aid in the easy insertion of MNs within the skin, thereby requiring lower penetration forces [ 77 ]. However, too-fine or small-tip diameters can result in the premature fracture of the MNs during insertion [ 78 ]. Thus, an optimal tip diameter is desirable based on both the base diameter and aspect ratio of the MNs.…”

Section: Resultsmentioning

confidence: 99%

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Aldawood,

Parupelli,

Andar

et al. 2024

Pharmaceutics

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Microneedle (MN) technology is an optimal choice for the delivery of drugs via the transdermal route, with a minimally invasive procedure. MN applications are varied from drug delivery, cosmetics, tissue engineering, vaccine delivery, and disease diagnostics. The MN is a biomedical device that offers many advantages including but not limited to a painless experience, being time-effective, and real-time sensing. This research implements additive manufacturing (AM) technology to fabricate MN arrays for advanced therapeutic applications. Stereolithography (SLA) was used to fabricate six MN designs with three aspect ratios. The MN array included conical-shaped 100 needles (10 × 10 needle) in each array. The microneedles were characterized using optical and scanning electron microscopy to evaluate the dimensional accuracy. Further, mechanical and insertion tests were performed to analyze the mechanical strength and skin penetration capabilities of the polymeric MN. MNs with higher aspect ratios had higher deformation characteristics suitable for penetration to deeper levels beyond the stratum corneum. MNs with both 0.3 mm and 0.4 mm base diameters displayed consistent force–displacement behavior during a skin-equivalent penetration test. This research establishes guidelines for fabricating polymeric MN for high-accuracy and low-cost 3D printing.

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Section: Resultsmentioning

confidence: 99%

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Aldawood,

Parupelli,

Andar

et al. 2024

Pharmaceutics

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Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems

Han,

Choi,

Kang

2024

Adv Healthcare Materials

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Transdermal healthcare systems have gained significant attention for their painless and convenient drug administration, as well as their ability to detect biomarkers promptly. However, the skin barrier limits the candidates of biomolecules that can be transported, and reliance on simple diffusion poses a bottleneck for personalized diagnosis and treatment. Consequently, recent advancements in transdermal transport technologies have evolved toward active methods based on external energy sources. Multiple combinations of these technologies have also shown promise for increasing therapeutic effectiveness and diagnostic accuracy as delivery efficiency is maximized. Furthermore, wearable healthcare platforms are being developed in diverse aspects for patient convenience, safety, and on‐demand treatment. Herein, a comprehensive overview of active transdermal delivery technologies is provided, highlighting the combination‐based diagnostics, therapeutics, and theragnostics, along with the latest trends in platform advancements. This offers insights into the potential applications of next‐generation wearable transdermal medical devices for personalized autonomous healthcare.

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A Hollow Microneedle Equipped with a Micropillar for Improved Needle Insertion and Injection of Drug Solution

Futaki,

Inamura,

Nishimura

et al. 2024

Pharm Res

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An analysis of the relationship between microneedle spacing, needle force and skin strain during the indentation phase prior to skin penetration

Cited by 3 publications

References 19 publications

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

3D Printing of Biodegradable Polymeric Microneedles for Transdermal Drug Delivery Applications

Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems

A Hollow Microneedle Equipped with a Micropillar for Improved Needle Insertion and Injection of Drug Solution

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