An Analysis of the Quality of Cartilage Repair Studies

Jakobsen, Rune Bruhn; Engebretsen, Lars; Slauterbeck, James R.

doi:10.2106/jbjs.d.02904

Cited by 218 publications

(201 citation statements)

References 66 publications

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“…Coleman [6] reported major methodological deficiencies in studies reporting surgical outcome for patellar tendinopathy. Similar low-methodological qualities were identified by Jakobsen et al [11] and Tallon et al [16] for surgical outcome studies on cartilage repair and Achilles tendinopathy, respectively. Hence, we conducted this study to analyse the quality of all the studies which have reported outcome following cemented totaljoint arthroplasty of the thumb and have suggested few recommendations to minimise this problem.…”

Section: Introductionsupporting

confidence: 68%

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Analysis of methodological deficiencies of studies reporting surgical outcome following cemented total-joint arthroplasty of trapezio-metacarpal joint of the thumb

Sambandam

Gul

Priyanka

2006

International Orthopaedics (SICO

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Cemented total-joint arthroplasty has been increasingly used in the treatment of end stage arthritis of the thumb trapeziometacarpal joint. Evidence supporting its use in the treatment of trapeziometacarpal disorders in the literature is very limited. Most hand surgeons agree that there are concerns about the methodological quality of the limited literature available. In this study, we analysed the methodological quality of the outcome studies on cemented total-joint arthroplasty of the thumb. We included all the outcome studies published in the English literature on cemented total-joint arthroplasty of the trapeziometacarpal joint of thumb. We analysed these studies for methodological deficiencies and quality of outcome reporting based on the recommendations given by Coleman et al. Our study revealed that there were no uniform standards of outcome reporting. The mean Coleman score for the studies dealing with cemented total-joint arthroplasty of the thumb was 42.9. Major deficiencies were identified in areas like subject selection criteria (0/15), type of study (5.7/15), description of surgical procedure (3.7/5), description of the rehabilitation protocol (2/10), outcome measures (4.4/10) and outcome assessment (3.9/15). The methodological quality of the studies published within the last 10 years (49.9±9.7) was found to be slightly better than the studies published over 10 years ago (39.7±7.8). Our study highlights the need for more evidence in the form of randomised controlled prospective studies conducted with good methodological quality, comparing the cemented total-joint arthroplasty of the thumb to other procedures available for the treatment of disorders of the thumb. Further, to improve the standards of reporting, journal editors should try to standardise the outcome of the reporting by following the surgical procedures on the thumb.Résumé L'usage des prothèses totales cimentées dans le traitement des arthroses sévères trapézométarcarpiennes est en augmentation. Les preuves en faveur de cette utilisation sont rares. La plupart des chirurgiens de la main s'accordent à dire que les études de la littérature ont une méthodologie douteuse. Nous avons analysé dans cette étude la qualité méthodologique de la littérature pour les arthroplasties cimentées. Nous avons inclus pour cette étude tous les résultats publiés dans la littérature anglo-saxonne pour ce type de prothèses. Nous avons étudié les méthodologies et la qualité des résultats selon les recommandations de Coleman et al. Notre étude nous permet de montrer qu'il n'y a pas de standard uniforme pour valider ces résultats. Le score de Coleman et al. dans ces études a été de 42.9 (déviation standard [SD]-9.4). Les problèmes principaux que nous avons identifiés reposent sur les critères de sélection (0/15), le type d'études (5.7/15), la description du traitement chirurgical (3.7/5), la description du protocole de rééducation (2/10), les mesures de surveillance (4.4/10) et le devenir des patients (3.9/15). Pour la qualité méthod-International Orthop...

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Section: Introductionsupporting

confidence: 68%

“…However, there have been no analyses about the quality of these outcome studies. Methodological deficiencies have been reported in articles reporting surgical outcome for various other conditions [6,11,16]. Coleman [6] reported major methodological deficiencies in studies reporting surgical outcome for patellar tendinopathy.…”

Section: Introductionmentioning

confidence: 99%

Analysis of methodological deficiencies of studies reporting surgical outcome following cemented total-joint arthroplasty of trapezio-metacarpal joint of the thumb

Sambandam

Gul

Priyanka

2006

International Orthopaedics (SICO

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“…However, in the case of cartilage repair, which is a key target for regenerative medicine, several cell-based repair strategies already exist, including implantation of cultureexpanded articular chondrocytes, implantation of culture-expanded MSCs, and bone microfracture techniques, among other strategies (14,24,25). Admittedly, the desired outcome of cartilage repair has been inconsistent, and sometimes only modest results have been achieved, but investigators in the field recognize that factors other than the cells themselves, including growth factors, tissue scaffolds, the diseased microenvironment (26), and alignment of the joint (27), may have a crucial influence on the outcome (Table 2). Therefore, regardless of the source of the stem cell, these factors will have to be understood to maximize the benefits of stem cell therapy.…”

Section: Existing Msc-based Cartilage and Bone Therapiesmentioning

confidence: 99%

“…Indeed, cells with analogous biologic features have been isolated from other tissues, including synovial membrane (26,73), synovial fluid (33), periosteum (74,75), trabecular bone (76), and adipose tissue (77). Regardless of their source, MSCs possess multipotency and appear to have distinctive features in vitro and in vivo.…”

Section: Development Of Novel Therapies Based On Msc Tissue Specificimentioning

confidence: 99%

Lessons from musculoskeletal stem cell research: The key to successful regenerative medicine development

McGonagle

Bari

Arnold

et al. 2007

Arthritis & Rheumatism

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Polystyrene and poly(butyl acrylate) were grafted from silicon wafer surface by reversible addition‐fragmentation chain transfer (RAFT) polymerization. Three RAFT agents were immobilized onto silicon wafer through their leaving/initiating groups (R group). Grafting polymerization of butyl acrylate (BA) and styrene (St) was then carried out from the immobilized RAFT agents. The immobilization of the RAFT agents and the subsequent grafting polymerization of St and BA were evaluated by ellipsometry and X‐ray photoelectron spectroscopy. It was found that type of monomer, structure of RAFT agent, and local RAFT concentration on the surface have dramatic influences on the thickness of grafted polymer layer. The grafting polymerization with more severe rate retardation effect yielded thinner polymer films on the silicon wafer. Selection of a RAFT agent with little rate retardation was critical in the grafting polymerization to achieve thick films. © 2007 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 46: 970–978, 2008

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“…Abrasion arthroplasty, subchondral drilling, autologous osteochondral grafts, periosteal-perichondral grafts, chon-drocyte transplantation and gene therapy have been developed for the treatment of focal chondral lesions with acceptable results [1,7,12,19,22]. Successful long-term clinical results are obtained with the use of an autologous osteochondral cylindrical graft for the repair of osteochondral defects [5,11,18].…”

Section: Introductionmentioning

confidence: 99%

The effect of fibroblast growth factor-2 on autologous osteochondral transplantation

Nakayama

Fujioka

Nagura

et al. 2007

International Orthopaedics (SICO

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In this study, we performed a mechanical analysis of the effect of fibroblast growth factor-2 (FGF-2) on autologous osteochondral transplantation in a rabbit model. A full-thickness cartilage defect (diameter: 5 mm; depth: 5 mm) made in the right femoral condyle was treated with osteochondral transplantation using an osteochondral plug (diameter: 6 mm; depth: 5 mm) taken from the left femoral condyle. The animals were divided into three groups: Group I, the defect was filled with 0

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An Analysis of the Quality of Cartilage Repair Studies

Abstract: Therapeutic Level III.

Cited by 218 publications

References 66 publications

Analysis of methodological deficiencies of studies reporting surgical outcome following cemented total-joint arthroplasty of trapezio-metacarpal joint of the thumb

Analysis of methodological deficiencies of studies reporting surgical outcome following cemented total-joint arthroplasty of trapezio-metacarpal joint of the thumb

Lessons from musculoskeletal stem cell research: The key to successful regenerative medicine development

The effect of fibroblast growth factor-2 on autologous osteochondral transplantation

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