An analysis of the progression and development of metastases in patients receiving x-radiation in hyperbaric oxygen

Brenk, H.A.S. van den; Madigan, James P.; Kerr, R. C.

doi:10.1016/s0009-9260(67)80125-9

Cited by 17 publications

(11 citation statements)

References 5 publications

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“…In the past, many similar experiments were performed to culture cells but there were a few studies in vivo 2 , 7 , 14 , 15 . In the clinical study of advanced epithelial tumors of the head and neck, treatment with HBO markedly suppressed local tumor growth and significantly suppressed remote metastasis of a tumor to the lung 7 , 10 . HBO has been applied to clinical practice 16 ; however, the effect of HBO on tumors has not been clarified.…”

Section: Discussionmentioning

confidence: 99%

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The Enhancing Effects of Hyperbaric Oxygen on Mouse Skin Carcinogenesis

et al. 2014

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The effects of hyperbaric oxygen (HBO) on mouse skin two-stage chemical carcinogenesis were examined. Six-week-old inbred CD-1 female mice were divided into the following five groups: group 1, normoxia and application of 25 nmol 7,12-dimethylbenz[a]anthracene (DMBA) and 8.5 nmol 12-O-tetradecanoylphorbol-13-acetate (TPA) (n=19); group 2, HBO and DMBA/TPA (n=21); group 3, HBO and DMBA/acetone (n=3); group 4, normoxia and acetone (n=3); and group 5, non-treatment group (n=5). HBO was started at the same time as DMBA. Mice were euthanized at 23 weeks after the start of the experiment. Mice in group 2 showed the occurrence of tumors at 8 weeks after the beginning of the experiment, while the occurrence of tumors in mice in group 1 was observed beginning at 9 weeks. There was a difference in occurrence among low-grade papillomas, high-grade papillomas and SCCs in both groups 1 and 2 by the χ2-test at end of the experiment (p<0.05). The Ki-67 labeling indices of tumors revealed that the percentages of positive cells in low-grade papillomas in groups 1 and 2 were 15.27 ± 2.54% and 29.67 ± 2.82%, respectively (p<0.01). The results suggested that the tumors in group 2, which was treated with HBO, were more progressive than those in group 1, which was not treated with HBO. In this study, HBO accelerated tumor cell proliferation and advanced tumor progression in skin carcinogenesis by DMBA/TPA.

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Section: Discussionmentioning

confidence: 99%

“…However, many clinicians and researchers do not yet recognize HBO therapy as an effective mechanism of cancer treatment. It still remains controversial in cancer treatment 9 , 10 .…”

Section: Introductionmentioning

confidence: 99%

The Enhancing Effects of Hyperbaric Oxygen on Mouse Skin Carcinogenesis

et al. 2014

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“…Further, the logistics of combined HBO/radiation protocols make them difficult to carry out. Finally, concern has been expressed over the possibility of increased risk of distant metastases with combination radiation therapy and HBO, 18 although other data did not show any increase in number or rate of growth of metastases outside the radiation‐treated field 10 . Experimental studies in animals have also resulted in conflicting data.…”

Section: Discussionmentioning

confidence: 99%

“…Others dispute these findings 7 . Further, some studies suggest an increased metastasis rate in patients irradiated in a hyperbaric field, 8 , 9 but others disagree with these conclusions 10–12 . An actual mechanism by which HBO influences tumor growth remains to be elucidated.…”

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confidence: 99%

Rapid Progression of Head and Neck Squamous Carcinoma after Hyperbaric Oxygenation

Martinez¹,

Bradfield

Kinsella

et al. 1996

Otolaryngol.--head neck surg.

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ILlMyperbaric oxygen (HBO) therapy is sometimes indicated in the course of treatment of head and neck cancer patients for the treatment of persistent infection 1 or bone or cartilage necrosis after radiation therapy 2-4 or as an adjunct to reconstructive proced~ares/ Recurrent or residual tumor may be present in patients undergoing HBO. Previous experimental studies have been inconclusive regarding the effect of HBO on tumor cells. Concerns have been raised regarding whether HBO leads to tumor activation. Some evidence suggests that HBO may have two independent effects on carcinogenesisinhibiting the development of new tumors while enhancing the growth of existing lesions. 6 Others dispute these findings. 7 Further, some studies suggest an increased metastasis rate in patients irradiated in a hyperbaric field, s,9 but others disagree with these conclusions.l°-12 An actual mechanism by which HBO influences tumor growth remains to be elucidated. CASE REPORTSCase ~!. A 30-year-old male tobacco chewer was treated for a T4N0 lateral tongue and tongue base lesion with wide excision, partial mandibulectomy, and right modified radical neck dissection. A radial forearm flap was used for

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“…In some series and studies, HBO has seemed to promote tumor growth, 1‐3 while other reports show no initiating or promoting effect 4‐7 . The same dichotomy exists for evidence on the effect of HBO on distant metastasis rate 2,6,8,9 . In a prior study at this institution, HBO was administered during the induction of chemical carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

Effect of Hyperbaric Oxygenation on Existing Oral Mucosal Carcinoma

et al. 1996

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Hyperbaric oxygen therapy (HBO) is used to treat some complications of head and neck carcinoma treatment. Several patients treated with HBO have had rapid growth of a clinically cured squamous cell carcinoma. Prior studies have produced conflicting evidence about the effect of HBO on tumor growth. This study was undertaken to determine the effects of HBO on established squamous cell carcinoma. Forty Golden Syrian hamster cheek-pouch carcinomas were induced with the established chemical carcinogen 9,10-dimethyl-1,2-benzanthracene. Twenty hamsters underwent 30 HBO dives for 60 minutes each to 2.81 atm, while 20 served as controls. At necropsy, animals receiving HBO therapy had significantly smaller tumors (P < .05) and showed a trend toward fewer cervical metastases (P < .06). HBO therapy with coexistent carcinoma inhibited the established tumor's growth.

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An analysis of the progression and development of metastases in patients receiving x-radiation in hyperbaric oxygen

Cited by 17 publications

References 5 publications

The Enhancing Effects of Hyperbaric Oxygen on Mouse Skin Carcinogenesis

The Enhancing Effects of Hyperbaric Oxygen on Mouse Skin Carcinogenesis

Rapid Progression of Head and Neck Squamous Carcinoma after Hyperbaric Oxygenation

Effect of Hyperbaric Oxygenation on Existing Oral Mucosal Carcinoma

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