An analysis of the predictors of comorbid psychopathology, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder

Mannion, Arlene; Leader, Geraldine

doi:10.1016/j.rasd.2013.10.002

Cited by 41 publications

(33 citation statements)

References 25 publications

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“…It may be possible that children are presenting with non-gastrointestinal manifestations of GI symptoms. This finding is supported byBuie et al (2010) who discussed how problem behavior and sleep problems may actually be presentation of GI disorders Mannion and Leader (2013a). found a relationship between GI symptoms and sleep problems.…”

mentioning

confidence: 72%

“…Family history of OCD was associated with nausea. Mannion and Leader (2013a) found that gastrointestinal symptoms predicted worry/depressed and avoidant behavior on the ASD-CC, which together form a measure of anxiety. More research needs to be conducted on the relationship between anxiety and GI symptoms.…”

Section: Discussionmentioning

confidence: 98%

“…Mannion et al (2013) found that 80.9% of participants presented with sleep problems. Mannion and Leader (2013a) found that 67.8% of participants presented with both sleep problems and gastrointestinal symptoms, while 12.6% presented with sleep problems only. This would suggest that sleep problems and gastrointestinal symptoms seem to commonly occur together in children and adolescents with ASD.…”

Section: Sleep Problemsmentioning

confidence: 96%

“…Research has also investigated the frequency and predictors of comorbidity (Mannion et al, 2013;Mannion & Leader, 2013a). Much more research is needed into many areas of comorbidity in ASD including longitudinal research.…”

Section: Comorbidity In Autism Spectrum Disorder (Asd)mentioning

confidence: 99%

“…These branches will allow determination of rates of these categories as well. It has been used in published research (Mannion et al, 2013;Mannion & Leader, 2013a;Mazefsky, Schreiber, Olino, & Minschew, 2014;Mazurek et al, 2013). disorder, eating disorders/difficulties, OCD, specific phobias, and tic disorders.…”

Section: Gastrointestinal Symptom Inventory the Gastrointestinal Symmentioning

confidence: 99%

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An investigation of comorbid psychological disorders, sleep problems, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder: A two year follow-up

Mannion

Leader

2016

Research in Autism Spectrum Disorders

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Research has recently focused on studying comorbidity in the autism spectrum but little research has been conducted in follow-up studies or conducting longitudinal research into these conditions. Mannion, Leader, and Healy (2013) examined the frequency of comorbid disorders in children and adolescents with autism spectrum disorder and the predictors of sleep problems. The current study is a follow-up study conducted two years later with 56 participants. Age, gender, level of intellectual disability, presence of epilepsy, attention deficit/hyperactivity disorder (AD/HD) and an anxiety disorder were assessed, along with administering the Autism Spectrum Disorder-Comorbid for Children (ASD-CC) , the Children's Sleep Habits Questionnaire (CSHQ) and Gastrointestinal Symptom Inventory. The aim of the study was to determine if comorbid symptoms changed over time. An additional aim was to explore if there is a relationship between family medical history and history of autoimmune diseases, and child comorbid conditions. Sleep problems persisted in 91.5% of participants. Gastrointestinal symptoms persisted in 84.4% of participants. There was a significant difference between over-eating at baseline and at two-year follow-up, where over-eating became more severe over time. It was found that 92.9% of participants presented with a family history of autoimmune disease. The most common autoimmune diseases were osteoarthritis, psoriasis and hypothyroidism. The associations between familial autoimmune diseases and child comorbid conditions are discussed in the study.

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mentioning

confidence: 72%

Section: Discussionmentioning

confidence: 98%

Section: Sleep Problemsmentioning

confidence: 96%

Section: Comorbidity In Autism Spectrum Disorder (Asd)mentioning

confidence: 99%

Section: Gastrointestinal Symptom Inventory the Gastrointestinal Symmentioning

confidence: 99%

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An investigation of comorbid psychological disorders, sleep problems, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder: A two year follow-up

Mannion

Leader

2016

Research in Autism Spectrum Disorders

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Prevalence of gastrointestinal symptoms among autistic individuals, with and without co‐occurring intellectual disability

et al. 2023

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Gastrointestinal symptoms (GI) are very common among individuals on the autism spectrum. Prior research reports mixed findings regarding whether individuals with autism and co‐occurring intellectual disability (ID) have elevated risk of gastrointestinal symptoms relative to individuals with autism alone. GI symptoms can be challenging to assess in individuals with autism spectrum disorder (ASD) and/or ID given challenges with language, communication, and interoception. Prior research has tended to only include individuals with documented presence or absence of GI symptoms or conditions, that is, to exclude observations in which there is uncertainty regarding presence of GI symptoms. Therefore, none of the prior autism studies reported the association between ID and the certainty regarding presence or absence of GI symptoms. The objective of this study was to examine differences in parental certainty and odds of reporting gastrointestinal signs and symptoms among children on the autism spectrum, with and without intellectual disability. Participants were 308 children (36% ID) with a clinical diagnosis of autism spectrum disorder (6–17 years). Parents endorsed whether their child had experienced or displayed a range of signs or symptoms related to GI problems in the past 3 months. Parents of autistic children with ID were less certain about the presence of more subjective symptoms, including abdominal pain, nausea, and bloating. Conversely, certainty regarding more objective signs (e.g., constipation, diarrhea, spitting up, etc.) was not significantly different. More accurate measures for GI signs/symptoms are needed for this population.

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Comorbidity and the Need for Interdisciplinary Treatments

Matson

Burns

2019

Handbook of Interdisciplinary Treatments for Autism Spectrum Disorder

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An analysis of the predictors of comorbid psychopathology, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder

Cited by 41 publications

References 25 publications

An investigation of comorbid psychological disorders, sleep problems, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder: A two year follow-up

An investigation of comorbid psychological disorders, sleep problems, gastrointestinal symptoms and epilepsy in children and adolescents with autism spectrum disorder: A two year follow-up

Prevalence of gastrointestinal symptoms among autistic individuals, with and without co‐occurring intellectual disability

Comorbidity and the Need for Interdisciplinary Treatments

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