Abstract:The objective of this study was to determine optimum extrusion-spheronisation parameters for producing bioactive-loaded beads with maximum consistency. The Taguchi method for robust engineering design was applied, using an L 9 orthogonal array (fractional factorial design). The processing parameters analysed were spheronising speed, time and the amount of granulating liquid. The potential importance of some interactive effects was assessed by applying a response surface analysis to the data. The amount of gran… Show more
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.