“…Issues to consider as network-based studies of neuropsychiatric disorders move forward Molecular interactions, pathways, and networks are context-specific Whether two molecules interact strongly depends on their biological context, so molecular networks in general, and modules in particular, are context-specific. They can be tissue-specific [23,109], allele-specific [45,93,110], splicing isoform-specific [111], cell-type-specific [43], or brain layerspecific [41,42]. They also vary over time.…”