An analysis of Papanicolaou smear before treatment for adenocarcinoma <i>in situ</i> of the uterine cervix in 65 cases

Gastric‑type endocervical adenocarcinoma: A report of two cases

“…In order to improve the diagnostic accuracy of GEA, in addition to imaging methods, other screening methods must be used in combination, such as cytological examination (including TCT examination and HPV examination), colposcopy and cervical biopsy ( 23 ). However, for GEA, some studies have found that the accuracy of detecting cervical invasive adenocarcinoma based on Pap smears is only 45–76% ( 24 , 25 ). In the present study, the preoperative workup of patient A, including cytology, colposcopy and a biopsy by cervical conization, was negative.…”

“…The other reason ( 27 ) is that the atypia of GEA itself is easily overlooked in smears, as its tissue is well differentiated and easily confused with benign lesions. The retrospective analysis of Papanicolaou smears of patients with invasive adenocarcinoma of the cervix, which appear negative, has found false-negative rates as high as 40–60% ( 25 ). After reviewing the literature on GEA, the Department of Pathology of the Women's Hospital, School of Medicine, Zhejiang University, re-studied the previously negative Pap smears, and finally >20 cases of GEA were diagnosed.…”