An analysis of outcomes, after re-irradiation by HDR (high-dose-rate) brachytherapy, among patients with locally recurrent nasopharyngeal carcinoma (NPC)

Terlikiewicz, Joanna; Makarewicz, Roman; Lebioda, Andrzej; Kabacińska, R.; Biedka, Marta

doi:10.1016/s1507-1367(05)71092-0

Cited by 4 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a larger study, rT stage was found to be a statistically significant factor for LC but not disease specific survival or OS (Law et al, 2002). Conversely, rT stage was found to be statistically significant for OS but not overall RFS (Terlikiewicz et al, 2005). The type of recurrence was shown to be a significant prognostic factor for LC from other studies.…”

Section: Resultsmentioning

confidence: 68%

“…However, normalised total brachytherapy dose was not demonstrated to have a statistically significant effect on OS. Only the total dose from the EBRT was shown to be associated with a significant effect on OS (Terlikiewicz et al, 2005).…”

Section: Resultsmentioning

confidence: 96%

“…A recent study employing ICBT using HDR afterloading technique in treating recurrent NPC patients reported median overall recurrence free survival (RFS) of 26 months with 3 and 5-year disease free survival (DFS) rate of 50% and 25% respectively. A higher normalized total dose was associated with a higher chance of LC (Terlikiewicz et al, 2005). One study investigating 91 patients with non-metastatic locally recurrent NPC treated with EBRT with or without ICBT reported 5 year DFS and OS of 33% and 33% respectively (Leung et al, 2000).…”

Section: Treatment Outcome With Brachytherapy For Recurrent Nasopharymentioning

confidence: 99%

See 2 more Smart Citations

Treatment Outcome with Brachytherapy for Recurrent Nasopharyngeal Carcinoma

Cheah¹,

Lau²,

Yusof³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: To evaluate the treatment outcome and major late complications of all patients with recurrent nasopharyngeal carcinoma (NPC) treated with intracavitary brachytherapy (ICBT) in Hospital Kuala Lumpur. Materials and Methods: This retrospective study was conducted at the Department of Radiotherapy and Oncology, Hospital Kuala Lumpur, Malaysia. All patients with histologically confirmed recurrent NPC in the absence of distant metastasis treated in the period 1997-2010 were included in this study. These patients were treated with ICBT alone or in combination with external beam radiotherapy (EBRT). Treatment outcomes measured were local recurrence free survival (LRFS), disease free survival (DFS) and overall survival (OS). Results: Thirty three patients were eligible for this study. The median age at recurrence was 56 years with a median time to initial local recurrence of 27 months. Majority of patients were staged as rT1-2 (94%) or rN0 (82%). The proportion of patients categorised as stage III-IV at first local recurrence was only 9%. Twenty one patients received a combination of ICBT and external beam radiotherapy while 12 patients were treated with ICBT alone. Median interval of recurrence post re-irradiation was 32 months (range: 4-110 months). The median LRFS, DFS and OS were 30 months, 29 months and 36 months respectively. The 5 year LRFS, DFS and OS were 44.7%, 38.8% and 28.1% respectively. The N stage at recurrence was found to be a significant prognostic factor for LRFS and DFS after multivariate analysis. Major late complications occurred in 34.9% of our patients. Conclusions: Our study shows ICBT was associated with a reasonable long term outcome in salvaging recurrent NPC although major complications remained a significant problem. The N stage at recurrence was a significant prognostic factor for both LRFS and DFS.

show abstract

Section: Resultsmentioning

confidence: 68%

Section: Resultsmentioning

confidence: 96%

Section: Treatment Outcome With Brachytherapy For Recurrent Nasopharymentioning

confidence: 99%

See 1 more Smart Citation

Treatment Outcome with Brachytherapy for Recurrent Nasopharyngeal Carcinoma

Cheah¹,

Lau²,

Yusof³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…For instance, Cheah et al (29) reported that the 5-year LRFS, DFS, and OS of 33 patients with rNPC who were treated with ICBT alone or in combination with EBRT were 44.7, 38.8, and 28.1%, respectively. A study in which patients with rNPC were treated with ICBT using the HDR afterloading technique reported a median overall LRFS of 26 months, with 3- and 5-year LRFS of 50 and 25%, respectively (30). Additionally, Law et al (31) reported that BT was an effective salvage treatment for patients with early T stage rNPC, and their 5-year local control and OS were 85 and 61.3%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Long-Term Outcomes of Three-Dimensional High-Dose-Rate Brachytherapy for Locally Recurrent Early T-Stage Nasopharyngeal Carcinoma

Lin

Ouyang

et al. 2019

Front. Oncol.

View full text Add to dashboard Cite

Background: Brachytherapy (BT) is one of the techniques available for retreatment of patients with locally recurrent nasopharyng eal carcinoma (rNPC). In this study, we evaluated the treatment outcome and late toxicities of three-dimensional high-dose-rate brachytherapy (3D-HDR-BT) for patients with locally rNPC. Materials and Methods: This is a retrospective study involving 36 patients with histologically confirmed rNPC from 2004 to 2011. Of the 36 patients, 17 underwent combined-modality treatment (CMT) consisting of external beam radiotherapy (EBRT) followed by 3D-HDR-BT, while the other 19 underwent 3D-HDR-BT alone. The median dose of EBRT for the CMT group was 60 (range, 50–66) Gy, with an additional median dose of BT of 16 (range, 9–20) Gy. The median dose for the 3D-HDR-BT group was 32 (range, 20–36) Gy. The measured treatment outcomes were the 5- and 10-year locoregional recurrence-free survival (LRFS), disease-free survival (DFS), overall survival (OS), and late toxicities. Results: The median age at recurrence was 44.5 years. The median follow-up period was 70 (range, 6–142) months. The 5-year LRFS, DFS, and OS for the entire patient group were 75.4, 55.6, and 74.3%, respectively, while the 10-year LRFS, DFS, and OS for the entire patient group were 75.4, 44.2, and 53.7%, respectively. The 10-year LRFS in the CMT group was higher than that in the 3D-HDR-BT-alone group (93.8 vs. 58.8%, HR: 7.595, 95%CI: 1.233–61.826, p = 0.025). No grade 4 late radiotherapy-induced toxicities were observed. Conclusions: 3D-HDR-BT achieves favorable clinical outcomes with mild late toxicity in patients with locally rNPC.

show abstract

“…However, radiotherapy resistance and the high rate of fatal complications may give rise to even worse prognoses 8 . In recent years, several novel salvage strategies have been shown to be effective in treating IrNPC, including intensity‐modulated radiotherapy (IMRT), stereotactic radiosurgery (SRS), brachytherapy, open nasopharyngectomy, and endoscopic nasopharyngectomy 9–13 . Even so, there is still no standardized management strategy for IrNPC, with each salvage strategy offering its own advantages and disadvantages.…”

Section: Introductionmentioning

confidence: 99%

Salvage treatments for locally recurrent nasopharyngeal cancer: Systematic review and meta‐analysis

Wang

Liao

et al. 2022

Head & Neck

View full text Add to dashboard Cite

The present study aimed to evaluate the effectiveness and safety of various salvage treatments to treat locally recurrent nasopharyngeal carcinoma (IrNPC). A comprehensive search was conducted to gather relevant research publications on salvage treatment for IrNPC. Specifically, 2‐, 3‐, and 5‐year overall survival were the primary outcome. A total of 89 studies with 101 cohorts were collected. Endoscopic nasopharyngectomy was found to be associated with a significantly improved 5‐year OS compared with CRT (p = 0.027) and IMRT (p = 0.016). Moreover, based on recurrence T classification, the 2‐, 3‐, and 5‐year OS were similar across different treatments. Endoscopic nasopharyngectomy was associated with a significant reduction in treatment‐related complications (grade ≥ 3) compared with IMRT (p < 0.001) and open nasopharyngectomy (p = 0.028). Endoscopic nasopharyngectomy may provide comparable treatment outcomes to re‐irradiation, while offering a better safety profile for selective patients with resectable IrNPC.

show abstract

An analysis of outcomes, after re-irradiation by HDR (high-dose-rate) brachytherapy, among patients with locally recurrent nasopharyngeal carcinoma (NPC)

Cited by 4 publications

References 31 publications

Treatment Outcome with Brachytherapy for Recurrent Nasopharyngeal Carcinoma

Treatment Outcome with Brachytherapy for Recurrent Nasopharyngeal Carcinoma

Long-Term Outcomes of Three-Dimensional High-Dose-Rate Brachytherapy for Locally Recurrent Early T-Stage Nasopharyngeal Carcinoma

Salvage treatments for locally recurrent nasopharyngeal cancer: Systematic review and meta‐analysis

Contact Info

Product

Resources

About