An analysis of green discoloration of urine caused by propofol infusion

Fujii-Abe, Keiko; Kawahara, Hiroshi; Fukayama, Haruhisa

doi:10.1016/j.jclinane.2016.08.032

Cited by 10 publications

(11 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“… Shioya et al [ 19 ] reported that green urine was associated with enterohepatic circulatory failure due to constipation and impaired peristalsis, supplement of albumin and erythrocytes as carrier proteins due to administration of an albumin preparation and concentrated red cells, and extrahepatic glucuronidation in the kidneys. Fujii-Abe et al [ 140 ] by performing liquid chromatography–mass spectrometry (LC-MS) registered 2 unique peaks in the green urine at 490 and 590 nm, with the complementary colors being orange and blue, respectively. It was assumed that green urine was observed because of a mixture of these 2 colors.…”

Section: Propofol Metabolism and Related Urine Discolorationmentioning

confidence: 99%

“…Fujii-Abe et al [ 140 ] by performing liquid chromatography–mass spectrometry (LC-MS) registered 2 unique peaks in the green urine at 490 and 590 nm, with the complementary colors being orange and blue, respectively. It was assumed that green urine was observed because of a mixture of these 2 colors.…”

Section: Propofol Metabolism and Related Urine Discolorationmentioning

confidence: 99%

See 1 more Smart Citation

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Dinis-Oliveira

2018

BioMed Research International

View full text Add to dashboard Cite

Propofol is an intravenous short-acting anesthetic widely used to induce and maintain general anesthesia and to provide procedural sedation. The potential for propofol dependency and abuse has been recognized, and several cases of accidental overdose and suicide have emerged, mostly among the health professionals. Different studies have demonstrated an unpredictable interindividual variability of propofol pharmacokinetics and pharmacodynamics with forensic and clinical adverse relevant outcomes (e.g., pronounced respiratory and cardiac depression), namely, due to polymorphisms in the UDP-glucuronosyltransferase and cytochrome P450 isoforms and drugs administered concurrently. In this work the pharmacokinetics of propofol and fospropofol with particular focus on metabolic pathways is fully reviewed. It is concluded that knowing the metabolism of propofol may lead to the development of new clues to help further toxicological and clinical interpretations and to reduce serious adverse reactions such as respiratory failure, metabolic acidosis, rhabdomyolysis, cardiac bradyarrhythmias, hypotension and myocardial failure, anaphylaxis, hypertriglyceridemia, renal failure, hepatomegaly, hepatic steatosis, acute pancreatitis, abuse, and death. Particularly, further studies aiming to characterize polymorphic enzymes involved in the metabolic pathway, the development of additional routine forensic toxicological analysis, and the relatively new field of ‘‘omics” technology, namely, metabolomics, can offer more in explaining the unpredictable interindividual variability.

show abstract

Section: Propofol Metabolism and Related Urine Discolorationmentioning

confidence: 99%

Section: Propofol Metabolism and Related Urine Discolorationmentioning

confidence: 99%

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Dinis-Oliveira

2018

BioMed Research International

View full text Add to dashboard Cite

show abstract

“…The urine color may turn to green due to constipation, impaired peristalsis and related impaired entero-hepatic circulation, use of albumin and erythrocytes as carrier proteins, extra-hepatic glucuronidation mainly occurring in the kidneys in patients receiving continuous propofol infusion. Green urine development is explained by phenolic metabolite formation in the liver and their urinary excretion [6]. Propofol infusion-related green urine is a benign condition and rarely encountered.…”

Section: Discussionmentioning

confidence: 99%

Green urine appearance in a patient with refractory status epilepticus due to propofol infusion

Demır¹

2018

Ann Clin Anal Med

View full text Add to dashboard Cite

“…Pseudomonas ile ilişkili idrar yolu infeksiyonu, özellikle diyabet hastalarında piyosiyanin ve pyoverdin pigmentlerinin üretimi nedeniyle yeşil idrar gelişimine neden olmaktadır [7] . Hastamız diyabetik değildi, idrar mikroskobu ve idrar kültüründe infeksiyon bulguları yoktu.…”

Section: Fenol Içeren Bileşiklerunclassified

Green Discoloration of Urine After Propofol Infusion: A Case Report

Miniksar¹,

Yücel²,

Aydoğan³

et al. 2020

GKDA Derg

View full text Add to dashboard Cite

Green discoloration of urine after propofol infusion is a reversible and rarely encountered clinical condition. In the intensive care patient, the clinician who is faced with a green color change in the urine is anxious primarily. Many clinicians are unfamiliar with this rare situation. Here, a patient who was followed up with HELLP Syndrome, had green color change in urine 40 hours after application of continuous propofol infusion in postoperative intensive care unit and returned to normal 6 hours after propofol discontinuation. Knowing such a reversible and rare clinical condition due to the commonly used propofol will reduce unnecessary anxiety and prevent unnecessary antibiotic use and laboratory tests.

show abstract

An analysis of green discoloration of urine caused by propofol infusion

Cited by 10 publications

References 11 publications

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects

Green urine appearance in a patient with refractory status epilepticus due to propofol infusion

Green Discoloration of Urine After Propofol Infusion: A Case Report

Contact Info

Product

Resources

About