An analysis of functional neuroimaging studies of dorsolateral prefrontal cortical activity in depression

Fitzgerald, Paul B.; Oxley, Tom; Laird, Angela R.; Kulkarni, Jayashri; Egan, Gary F.; Daskalakis, Zafiris J.

doi:10.1016/j.pscychresns.2006.04.006

Cited by 231 publications

(168 citation statements)

References 58 publications

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“…Although there is a relative consensus in the literature that the DLPFC is involved in the etiology of depression, the DLPFC is a relatively large area and there is no certainty as to which part of the DLPFC is likely to be involved critically in this disorder. In part to address this issue, we recently conducted a study, whereby we analyzed all functional neuroimaging studies that identified abnormalities in DLPFC in patients with depression (Fitzgerald et al, 2006c). Despite considerable heterogeneity in the results, there was some consistency in identification of changes in BA 9 across studies, although there was variability in the direction of the effects and hemisphere.…”

Section: Discussionmentioning

confidence: 99%

A Randomized Trial of rTMS Targeted with MRI Based Neuro-Navigation in Treatment-Resistant Depression

Fitzgerald

Hoy

McQueen

et al. 2009

Neuropsychopharmacol

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218

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The aim of this study is to investigate whether repetitive transcranial magnetic stimulation (rTMS) targeted to a specific site in the dorsolateral prefrontal cortex (DLPFC), with a neuro-navigational method based on structural MRI, would be more effective than rTMS applied using the standard localization technique. Fifty-one patients with treatment-resistant depression were randomized to receive a 3-week course (with a potential 1-week extension) of high-frequency (10 Hz) left-sided rTMS. Thirty trains (5 s duration) were applied daily 5 days per week at 100% of the resting motor threshold. Treatment was targeted with either the standard 5 cm technique (n ¼ 27) or using a neuro-navigational approach (n ¼ 24). This involved localizing the scalp location that corresponds to a specific site at the junction of Brodmann areas 46 and 9 in the DLPFC based on each individual subject's MRI scan. There was an overall significant reduction in the Montgomery-Asberg Depression Rating Scale scores over the course of the trial, and a better outcome in the targeted group compared with the standard localization group at 4 weeks (p ¼ 0.02). Significant differences were also found on secondary outcome variables. The use of neuro-navigational methods to target a specific DLPFC site appears to enhance response to rTMS treatment in depression. Further research is required to confirm this in larger samples, or to establish whether an alternate method based on surface anatomy, including measurement from motor cortex, can be substituted for the standard 5 cm method.

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Section: Discussionmentioning

confidence: 99%

A Randomized Trial of rTMS Targeted with MRI Based Neuro-Navigation in Treatment-Resistant Depression

Fitzgerald

Hoy

McQueen

et al. 2009

Neuropsychopharmacol

Self Cite

331

218

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“…Attenuated resting-state blood flow and glucose metabolism in prefrontal and anterior cingulate brain areas were reported in restingstate positron emission tomography studies. 6,7 Further, functional magnetic resonance imaging (fMRI) studies with cognitive paradigms taxing executive functions reported attenuated activations in the PFC and ACC when patients showed an impaired task performance in comparison with matched healthy control subjects 8 and a relative hyperactivity in patients when they were matched for task performance. 9 In our previous study with the Stroop Color-Word Test (SCWT), 10 an established neuropsychological test taxing cognitive inhibition processes, we directly tested the hypothesis of disrupted prefrontal and anterior cingulate functions.…”

Section: Introductionmentioning

confidence: 99%

Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression

Wagner

Koch

Schachtzabel

et al. 2008

Journal of Affective Disorders

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“…Dysfunction of this network might account for the negative interpretation bias common in MDD [64]. The DMN, consisting of the posterior cingulate cortex and medial prefrontal cortex (PFC) as its core areas [65,66] and the precuneus and temporo-parietal cortices, underlies the psychological process of introspection-the mind turning internally as it moves away from externally-concentrated thoughts [67][68][69]. A majority of studies have demonstrated that the DMN is hyperactive in MDD [70,71], and this may account for the rumination states in MDD [72].…”

Section: Mr Imaging Of Resting-state Functional Connectivitymentioning

confidence: 99%

Molecular, Functional, and Structural Imaging of Major Depressive Disorder

Zhang

Zhu

et al. 2016

Neurosci. Bull.

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Major depressive disorder (MDD) is a significant cause of morbidity and mortality worldwide, correlating with genetic susceptibility and environmental risk factors. Molecular, functional, and structural imaging approaches have been increasingly used to detect neurobiological changes, analyze neurochemical correlates, and parse pathophysiological mechanisms underlying MDD. We reviewed recent neuroimaging publications on MDD in terms of molecular, functional, and structural alterations as detected mainly by magnetic resonance imaging (MRI) and positron emission tomography. Altered structure and function of brain regions involved in the cognitive control of affective state have been demonstrated. An abnormal default mode network, as revealed by resting-state functional MRI, is likely associated with aberrant metabolic and serotonergic function revealed by radionuclide imaging. Further multi-modal investigations are essential to clarify the characteristics of the cortical network and serotonergic system associated with behavioral and genetic variations in MDD.

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An analysis of functional neuroimaging studies of dorsolateral prefrontal cortical activity in depression

Cited by 231 publications

References 58 publications

A Randomized Trial of rTMS Targeted with MRI Based Neuro-Navigation in Treatment-Resistant Depression

A Randomized Trial of rTMS Targeted with MRI Based Neuro-Navigation in Treatment-Resistant Depression

Enhanced rostral anterior cingulate cortex activation during cognitive control is related to orbitofrontal volume reduction in unipolar depression

Molecular, Functional, and Structural Imaging of Major Depressive Disorder

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