An analysis of factors influencing the outcome of postoperative irradiation for squamous cell carcinoma of the oral cavity

Parsons, James T.; Mendenhall, William M.; Stringer, Scott P.; Cassisi, Nicholas J.; Million, Rodney R.

doi:10.1016/s0360-3016(97)00152-1

Cited by 194 publications

(152 citation statements)

References 55 publications

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“…Thus, many years of clinical experience clearly demonstrate that postoperative radiotherapy in patients with advanced laryngeal cancer is an effective treatment. Numerous literature reports confirm that the main predictive factors are related to intraoperative and histopathological evaluation of the surgical specimen [13,16,17,18,19,21,29,31,32,33,34,35,36,37,38,39,40].…”

Section: Discussionmentioning

confidence: 96%

Histopathological factors influencing results of combined treatment in patients with laryngeal cancer

Mucha-Małecka¹,

Składowski²,

Lange³

2015

pjp

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The aim of the study was to assess the prognostic value of postoperative histopathological factors as well as the clinical usefulness of the modified risk score for recurrence. In a group of 197 patients with laryngeal cancer who underwent surgery followed by radiation therapy, partial resection was performed in 21.5% of patients and total resection in 78.5%. The majority of patients had T3 or T4 (74%) and N0 (63%) cancer. Macroscopically positive margins were reported in 10% of patients after partial resection and in 7% of patients after total resection, whereas microscopically positive margins were observed in 31% and 20% of cases, respectively. Extracapsular extension was observed in 22% of patients. In order to estimate local and nodal recurrence risk rates, criteria developed by Peters were used. Five-year local control (LC) was achieved in 88% of patients, disease-free survival (DFS) in 68% of patients and overall survival (OS) in 73% of patients. In the case of macroscopically positive margins, the 5-year DFS was 33% lower compared to radical surgery and 25% lower in the case of microscopically positive margins. The 5-year DFS was reduced by 29% due to extracapsular extension. Cox model analysis indicated that the degree of recurrence risk was the most potent independent prognostic factor for postoperative radiation therapy in laryngeal cancer. Negative histopathological factors influencing results of combined treatment of laryngeal cancer include macro-and microscopically positive margins, neck lymph node involvement and extracapsular extension.

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Section: Discussionmentioning

confidence: 96%

Histopathological factors influencing results of combined treatment in patients with laryngeal cancer

Mucha-Małecka¹,

Składowski²,

Lange³

2015

pjp

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“…(OTSCC) patients [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] . However, the contribution of perineural and vascular invasions to 3 prognosis remains unclear because of contradictory reports.…”

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confidence: 99%

“…Although the perineural invasion of head and neck cancer cell carcinoma was reported to be 2-82% 11,12 . In addition, some studies revealed a 13 correlation between perineural invasion and prognostic factors [11][12][13][14][15][16] . Some reports 14 suggested that perineural invasion had no effect on 5-year local control and OS 13, 14 .…”

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confidence: 99%

“…In addition, some studies revealed a 13 correlation between perineural invasion and prognostic factors [11][12][13][14][15][16] . Some reports 14 suggested that perineural invasion had no effect on 5-year local control and OS 13, 14 . In 15 contrast, other studies demonstrated that perineural invasion was significantly related to 16 local recurrence, regional metastasis, and survival 11,15 .…”

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confidence: 99%

“…In contrast, other reports demonstrated 22 that vascular invasion was not related to any prognostic factors [8][9][10][11][12][13][14][15][16][17][18][19] . In the current study, The current study also compared the relationship between perineural/vascular invasion …”

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confidence: 99%

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A clinicopathological study of perineural invasion and vascular invasion in oral tongue squamous cell carcinoma

Yanamoto

Takahashi

Yamada

et al. 2015

International Journal of Oral and Maxillofacial Surgery

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ABSTRACTretrospectively. Perineural and vascular invasions were found in 27.0 and 23.6% of 8 cases, respectively, and both had a strong relationship with histopathological nodal 9 status (P = 0.005). The 5-year disease specific survival and overall survival rates of 10 patients with perineural invasion were significantly lower than those of patients without 11 perineural invasion (P < 0.001 and P = 0.002, respectively). The 5-year disease specific 12 survival of UICC stage I and II cases with perineural/vascular invasion was 13 significantly lower than those without (P < 0.001 and P = 0.008, respectively).14 Perineural/vascular invasions are risk factors for regional metastasis and poor prognosis.

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The Impact of Adjuvant Radiotherapy on Survival in T1-2N1 Squamous Cell Carcinoma of the Oral Cavity

Shrime

Gullane²,

Dawson³

et al. 2010

Arch Otolaryngol Head Neck Surg

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An analysis of factors influencing the outcome of postoperative irradiation for squamous cell carcinoma of the oral cavity

Cited by 194 publications

References 55 publications

Histopathological factors influencing results of combined treatment in patients with laryngeal cancer

Histopathological factors influencing results of combined treatment in patients with laryngeal cancer

A clinicopathological study of perineural invasion and vascular invasion in oral tongue squamous cell carcinoma

The Impact of Adjuvant Radiotherapy on Survival in T1-2N1 Squamous Cell Carcinoma of the Oral Cavity

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