An analysis of energy-drink toxicity in the National Poison Data System

Seifert, Sara M.; Seifert, Steven A.; Schaechter, Judy; Bronstein, Alvin C.; Benson, Blaine E.; Hershorin, Eugene R.; Arheart, Kristopher L.; Franco, Vivian I.; Lipshultz, Steven E.

doi:10.3109/15563650.2013.820310

Cited by 100 publications

(84 citation statements)

References 30 publications

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“…Rising concerns about the safety of energy products, even though caffeine is thought to be relatively safe, suggest that systematic investigation of the risks and benefits of product use is warranted. 4,5 Energy products are advertised to decrease fatigue, and it is likely that these caffeinated beverages are effective in that regard. The administration of moderate (1-4 mg/kg) doses of caffeine reliably produces mild stimulant effects, such as enhancing subjective ratings of stimulation and wakefulness while decreasing ratings of mental fatigue.…”

Section: Introductionmentioning

confidence: 99%

Subjective State, Blood Pressure, and Behavioral Control Changes Produced by an “Energy Shot”

Marczinski

Stamates

Ossege

et al. 2014

Journal of Caffeine Research

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Background: Energy drinks and energy shots are popular consumer beverages that are advertised to increase feelings of alertness. Typically, these products include high levels of caffeine, a mild psychostimulant drug. The scientific evidence demonstrating the specific benefits of energy products to users in terms of subjective state and objective performance is surprisingly lacking. Moreover, there are rising health concerns associated with the use of these products. Therefore, the purpose of this study was to investigate the acute effects of a popular energy shot (5-Hour Energy Ò ) on subjective and objective measures that were assessed hourly for 6 hours following consumption. Methods: Participants (n = 14) completed a three-session study where they received the energy shot, a placebo control, and no drink. Following dose administration, participants completed subjective Profile of Mood States ratings hourly for 6 hours. Participants also repeatedly completed a behavioral control task (the cued go/no-go task) and provided blood pressure and pulse rate readings at each hour. Results: Consumption of the energy shot did improve subjective state, as measured by increased ratings of vigor and decreased ratings of fatigue. However, the energy shot did not alter objective performance, which worsened over time. Importantly, the energy shot elevated both systolic and diastolic blood pressure. Conclusions: Consumption of one energy shot may only result in modest benefits to subjective state. Individuals with preexisting hypertension or other medical conditions should be cautious about using these new consumer products.

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Section: Introductionmentioning

confidence: 99%

Subjective State, Blood Pressure, and Behavioral Control Changes Produced by an “Energy Shot”

Marczinski

Stamates

Ossege

et al. 2014

Journal of Caffeine Research

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“…32 An analysis of calls to the US National Poison Data System in a 12-month period in 2010/11 identified 4854 calls related to energy drinks, including 1480 calls that were not also related to alcohol; 15% were considered to be "moderate to major" adverse effects. 33 Similarly, calls to the Australian Poison Control Centre increased fivefold between 2004 and 2010, with cardiac events, hallucinations or seizures reported in 10% of cases. 34 The US Food and Drug Administration has identified more than 30 deaths linked with energy drinks, based on adverse events reports between 2004 and 2012.…”

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confidence: 99%

Adverse effects of caffeinated energy drinks among youth and young adults in Canada: a Web-based survey

2018

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“…These agents are known to stimulate catecholamine release, particularly dopamine and norepinephrine [26,27]. One common source of caffeine is the caffeinated energy drinks that have been reported recently to cause toxicity [28,29]. Cocaine has been well described to be associated with cardiovascular toxicity due to both catecholamine mediated effects as well as direct sodium channel blockade [30,31].…”

Section: Discussionmentioning

confidence: 99%

Ventricular Dysrhythmias Associated with Poisoning and Drug Overdose: A 10-Year Review of Statewide Poison Control Center Data from California

Al-Abri

Woodburn

Olson

et al. 2015

Am J Cardiovasc Drugs

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Key PointsThe most commonly involved therapeutic classes of drugs associated with ventricular fibrillation and/or tachycardia (VT/VF) were antidepressants (25 %) and stimulants (25 %).The drugs most commonly associated with torsade de pointes (TdP) were antidepressants (25 %) and methadone (25 %).Drug exposures with the greatest risk of death in association with VT/VF were antidepressant exposure [odds ratio (OR) 1.71] and antiarrhythmic exposure (OR 1.75), but neither association was statistically significant.

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An analysis of energy-drink toxicity in the National Poison Data System

Abstract: About half the cases of energy drink-related toxicity involved unintentional exposures by children < 6 years old. Educational campaigns and legal restrictions on the sale of energy drinks were associated with decreasing calls to poison centers for energy drink toxicity and are encouraged.

Cited by 100 publications

References 30 publications

Subjective State, Blood Pressure, and Behavioral Control Changes Produced by an “Energy Shot”

Subjective State, Blood Pressure, and Behavioral Control Changes Produced by an “Energy Shot”

Adverse effects of caffeinated energy drinks among youth and young adults in Canada: a Web-based survey

Ventricular Dysrhythmias Associated with Poisoning and Drug Overdose: A 10-Year Review of Statewide Poison Control Center Data from California

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