An analysis of a cytologically aberrant recessive visible mutation at the Notch locus in Drosophila melanogaster

Structural and Functional Dissection of the 5′ Region of the Notch Gene in Drosophila melanogaster

“…The nature of this factor is still unknown. In our work, a similar pleiotropic phenotype was demonstrated by the N fa-swb /dN trans-heterozygous females, and, apparently, it can be assumed that if such a regulatory factor exists, it is located within the region removed by the founder deletion, as rare surviving N fa-swb /dN females essentially mimicked the fa-swb-hairy phenotype described by [48].…”

“…In combination with N fa-swb , these mutations exhibited an enhanced phenotype: in N fa-swb fa g males, the wing veins were thickened and deltas were formed at the wing margins. There was enhancement of the hair distribution on the thorax and legs of N fa-swb spl flies [48]. This suggests that there are some regulatory elements in the introns of the Notch gene that interact with the functional sequences of the promoter region.…”

“…It was previously shown that the phenotype of the "classic" deletion N fa-swb can either be enhanced or suppressed in the presence of rearrangements located rather distal [15,19,20]. In the work by [48], a spontaneous variant of N fa-swb referred to as facet-strawberry-hairy (fa-swb h ) was detected. The homozygotes and hemizygotes demonstrated much more severe mutant phenotype manifestation than facet-strawberry animals.…”

An analysis of the Notch locus in Drosophila melanogaster

“…Based on these reasons, the latter explanation, for the negative results is favored. This interpretation, if correct, effectively eliminates the necessity to provide a specu lative, and more complex than desired, explanation for jj66hlO,l^ similar to that required by the cytogenetics of ^66i25^ 2^ general, the evidence favoring this explanation appears strong enough for tentative acceptance; but, it is clear that results of experiments now being conducted to resolve some of the equivocal features of (Welshons, For example, Welshons and Keppy (1975) and Keppy (1975) have And second, interest has focused on the actual partici patory role of the band in exchange events. For instance, Lefevre (1971) has demonstrated the apparently significant role played by heavy bands (i.e.…”

“…123 567 910 " 1 -56 1,2 iated with a visible, deficiency Olelshons and Keppy, 1975 (Table 2), Each was shown to recombine freely.…”