An Analysis of 72% Chromated Glycerin Used for Sclerotherapy

Abstract

Seventy-two percent CG has no contamination and maintains its reported potency up to 6 months while comparable with the cost of other commercially available sclerosants.

Allergic contact dermatitis from chromium after vein sclerosis with chromated glycerin

“…CG is a chemical irritant widely used for this purpose. Chromium is mixed with glycerin, as it is a potent coagulating factor, to enhance the glycerin sclerosing properties of glycerin 4 . Although it has not been approved by the Food and Drug Administration (FDA) for this use, it is widely used and it has been suggested to have a higher efficacy compared to polidocanol and sodium tetradecyl sulphate, which are alternative and FDA‐approved agents for sclerotherapy 5,6 …”

“…Chromium is mixed with glycerin, as it is a potent coagulating factor, to enhance the glycerin sclerosing properties of glycerin. 4 Although it has not been approved by the Food and Drug Administration (FDA) for this use, it is widely used and it has been suggested to have a higher efficacy compared to polidocanol and sodium tetradecyl sulphate, which are alternative and FDA-approved agents for sclerotherapy. 5,6 Allergic skin reactions following sclerotherapy may manifest as allergic contact dermatitis, but also contact urticaria and (a vaguely described) 'erythema'.…”

“…A diagnosis of FDE was made and a drug patch test was performed according to the recommendations of the European Society of Contact Dermatitis. 4 Allergens were obtained by preparation of powder of patient-brought commercially available pills of paracetamol, diclofenac sodium, ibuprofen and etoricoxib (Dolo-650 ® , Diclofen ® , Brufen ® and Coxib, respectively) and diluted to increasing concentrations of 1%, 5%, 10% and 20% in petrolatum. 5 Preparations were applied on lesional skin over the trunk and non-lesional skin over the mid-back with Finn chambers.…”