Abstract. We consider matrix Sturm-Liouville operators generated by the formal expression ). Let the matrix functions P := P (x), Q := Q(x) and R := R(x) of order n (n ∈ N) be defined on I, P is a nondegenerate matrix, P and Q are Hermitian matrices for x ∈ I and the entries of the matrix functions P −1 , Q and R are measurable on I and integrable on each of its closed finite subintervals. The main purpose of this paper is to find conditions on the matrices P , Q and R that ensure the realization of the limit-point case for the minimal closed symmetric operator generated by l k [y] (k ∈ N). In particular, we obtain limit-point conditions for Sturm-Liouville operators with matrix-valued distributional coefficients.