An Amylase-Producing Serous Cystadenocarcinoma of the Ovary

Hodes, M. E.; Sisk, Christine J.; Karn, Robert C.; Ehrlich, Clarence E.; Lehrner, Larry M.; Roth, Lawrence M.; Morley, Debra J.; Merritt, Donald

doi:10.1159/000226039

Cited by 24 publications

(7 citation statements)

References 10 publications

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“…Case reports based on the examination of fluid from ovarian cysts (19,20,23), Serum (16,18,22,24) and tumor tissue (2 5) indicate a possible role of fastmigrating forms of nonepancreatic origin markers in ovarian cancer. To investigate the diagnostic value of such amylase forms, we performed a prospective study in 160 patients, undergoing surgery because of an ovarian tumor.…”

Section: Introduction Materials and Methodsmentioning

confidence: 99%

Amylase Activity and Fast–Migrating Amylase Isoenzymes in Serum and Cyst Fluid from Patients with Ovarian Neoplasms

Henriksen

Brock

1988

Acta Obstet Gynecol Scand

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160 patients with various ovarian tumors were studied to establish whether total amylase activity and the occurrence of fast migrating amylase isoenzymes in serum could serve as indicators of ovarian cancer. It was found that patients with benign and malignant ovarian tumors could not be classified by means of total amylase activity. Electrophoretic separation of the amylases revealed fast-migrating forms in serum from 10 of 47 patients with malignant ovarian neoplasms; 8 of these 10, and altogether 19 of the 47 patients had a serous cystadenocarcinoma. Two of the 109 patients with benign ovarian tumors also showed the pattern with fast-migrating amylases; both of them had a serous cystadenoma. Four patients with borderline tumors showed normal amylase patterns. Tumor origin of these fast-migrating amylase forms in serum was substantiated by 1) amylase reactive cells detectable in tumor tissue, and 2) surgical removal of tumor followed by complete disappearance of the fast-migrating amylase forms in serum. Normal serum amylase patterns do not exclude the presence of a malignant ovarian tumor, but occurrence of these abnormal amylase forms in serum may indicate that an ovarian tumor is a cystadenocarcinoma.

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Section: Introduction Materials and Methodsmentioning

confidence: 99%

Amylase Activity and Fast–Migrating Amylase Isoenzymes in Serum and Cyst Fluid from Patients with Ovarian Neoplasms

Henriksen

Brock

1988

Acta Obstet Gynecol Scand

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“…Subsequently, hyperamylasaemia has been reported in a number of epithelial tumors including ovarian [2], endometrial [3], gastric [4] and breast [5] cancer.…”

Section: Introductionmentioning

confidence: 99%

Amylase: A disease activity index in multiple myeloma?

Pinelli

Bindi

Rosada

et al. 2006

Leukemia & Lymphoma

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This study reports a case of a patient with lambda-light chain multiple myeloma who developed a high hyperamylasaemia of the salivary type during the disease and soon afterwards died. Ectopic production of amylase by myeloma cells has been described in a few cases and demonstrated by tissue culture and immunohistochemical techniques. The common characteristics of these cases were: salivary amylase isoenzyme increase, high tumor mass, extensive extra-medullary spread, extensive bone destruction and poor prognosis. In patients with amylase-producing multiple myeloma, the onset of hyperamylasaemia heralds a rapid disease progression; therefore, in these patients, a simple test such as serum amylase may represent a reliable disease activity index and provide an additional prognostic information.

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“…Subsequently hyperamylasaemia has been described in a number of epithelial cancers. [1][2][3][4][5] More unusually. a raised amylase has been found in non-epithelial malignancies including multiple myeloma.v-"…”

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confidence: 99%