An amperometric glucose biosensor based on a GOx-entrapped TiO2–SWCNT composite

Dung, Nguyen Quoc; Patil, D.S.; Duong, Thanh–Tung; Jung, Hyuck; Kim, Dojin; Yoon, Soon‐Gil

doi:10.1016/j.snb.2012.01.008

Cited by 39 publications

(15 citation statements)

References 36 publications

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“…7(B)). The sensitivity of the enzyme electrode was calculated to be about 9.04 μA mM −1 cm −2 , which was higher than those reported at a GOx/TiO 2 -SWCNT/ITO-based glucose biosensor (5.32 μA mM −1 cm −2 ) [38] and GOx/titania sol/gel film (7.2μA mM −1 cm −2 ) [39]. Furthermore, according to the electrochemical version of the LineweaverBurk plot [40], the apparent Michaelis-Menten constant (K app m ) for the GOx/Fe 3 O 4 -RGO/MGCE is estimated to be 0.34 mM, which is smaller than that of GOx on nitrogen-doped carbon nanotubes of 2.2 mM [41].…”

Section: Electrocatalytical Behavior Of the Fecontrasting

confidence: 60%

Magnetic Fe3O4-Reduced Graphene Oxide Nanocomposites-Based Electrochemical Biosensing

et al. 2014

Nano-Micro Lett

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An electrochemical biosensing platform was developed based on glucose oxidase (GOx)/Fe3O4-reduced graphene oxide (Fe3O4-RGO) nanosheets loaded on the magnetic glassy carbon electrode (MGCE). With the advantages of the magnetism, conductivity and biocompatibility of the Fe3O4-RGO nanosheets, the nanocomposites could be facilely adhered to the electrode surface by magnetically controllable assembling and beneficial to achieve the direct redox reactions and electrocatalytic behaviors of GOx immobilized into the nanocomposites. The biosensor exhibited good electrocatalytic activity, high sensitivity and stability. The current response is linear over glucose concentration ranging from 0.05 to 1.5 mM with a low detection limit of 0.15 μM. Meanwhile, validation of the applicability of the biosensor was carried out by determining glucose in serum samples. The proposed protocol is simple, inexpensive and convenient, which shows great potential in biosensing application.

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Section: Electrocatalytical Behavior Of the Fecontrasting

confidence: 60%

Magnetic Fe3O4-Reduced Graphene Oxide Nanocomposites-Based Electrochemical Biosensing

et al. 2014

Nano-Micro Lett

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“…Due to the observably increasing request in diabetes clinical diagnostics [1] and the requirements in the food industry [2] and life science [3], the development of accurate, reliable and low cost devices for glucose detection becomes one of the most important scientific focuses. Since Updike and Hicks [4] detected glucose concentration in biological fluids for the first time by immobilizing glucose oxidase (GOD) on oxygen electrode in 1967, a great number of biosensors based on the GOD have been investigated [5][6][7][8]. These sensors could obtain high sensitivity and selectivity.…”

Section: Introductionmentioning

confidence: 99%

“…Due to its excellent properties for glucose detection, low cost and easy preparation method, this novel electrode active nanocomposite will be a promising candidate in the development of convenient and effective enzyme-free glucose sensor. 5 …”

Section: Introductionmentioning

confidence: 99%

A high performance nonenzymatic electrochemical glucose sensor based on polyvinylpyrrolidone–graphene nanosheets–nickel nanoparticles–chitosan nanocomposite

Liu

Guo

Dong

2015

Talanta

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“…Dung et al [42] described a TiO 2 -Single Wall Carbon Nanotube sensor that had a linear range of detection significantly less than the pH 12 silica sensor we produced, a similar response time to our sensor, and a lower sensitivity than our pH 12 silica sensor. The addition of carbon nanotubes are known to improve glucose sensor sensitivity and response time ; therefore it is encouraging that our sensitivity was comparable.…”

Section: Discussionmentioning

confidence: 69%

Silica-dispersed glucose oxidase for glucose sensing: In vitro testing in serum and blood and the effect of condensation pH

Harris

López

Reichert

2012

Sensors and Actuators B: Chemical

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The objectives of this study were to examine the feasibility of using glucose oxidase (GOx) dispersed in a silica matrix for glucose monitoring in whole blood, and then to assess whether the flexibility of silica sol-gel chemistry could be exploited to enhance glucose sensor performance and stability. Silica-dispersed GOx was deployed on platinized platinum (Pt) wire to form a Clark-type amperometric glucose sensor. Sensors were calibrated using buffered glucose standard solutions, and then tested against glucose spiked human serum and whole blood. All serum and whole blood measurements met the minimum FDA requirement of falling within the “A+B region” of a Clark Error Grid. To our knowledge this is the first report of using silica-dispersed GOx to measure glucose in whole blood. The effect of condensation pH on sensor performance was assessed by dispersing GOx in silica condensed at pH 3, 7 and 12, and then testing the sensor response against glucose calibration standards. The pH 12 silica sensors had statistically faster response time, and higher sensor sensitivity compared to pH 7, pH 3 silica and glutaraldehyde crosslinked sensors. Membranes of the pH 12 silica had statistically higher glucose diffusion coefficient than did the pH 7 and 3 sensors. GOx dispersed in pH 12 silica also had the longest half life. We hypothesize that the gel-like pH 12 silica gels provided reduced barriers to glucose diffusion, and the more aqueous microenvironment provided greater stability for the enzyme.

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An amperometric glucose biosensor based on a GOx-entrapped TiO2–SWCNT composite

Cited by 39 publications

References 36 publications

Magnetic Fe3O4-Reduced Graphene Oxide Nanocomposites-Based Electrochemical Biosensing

Magnetic Fe3O4-Reduced Graphene Oxide Nanocomposites-Based Electrochemical Biosensing

A high performance nonenzymatic electrochemical glucose sensor based on polyvinylpyrrolidone–graphene nanosheets–nickel nanoparticles–chitosan nanocomposite

Silica-dispersed glucose oxidase for glucose sensing: In vitro testing in serum and blood and the effect of condensation pH

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